微小RNA-133a在人类癌症中的新作用
Emerging roles of MiR-133a in human cancers.
作者信息
Hua Yu-Ting, Xu Wen-Xiu, Li Hui, Xia Min
机构信息
Department of Gastroenterology, Wuxi People's Hospital Affiliated to Nanjing Medical University, 299 Qingyang Road, Wuxi, Jiangsu 214023, China.
Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. China.
出版信息
J Cancer. 2021 Jan 1;12(1):198-206. doi: 10.7150/jca.48769. eCollection 2021.
MicroRNAs (miRNAs) can post-transcriptionally regulate the expression of cancer-relevant genes via binding to the 3'-untranslated region (3'-UTR) of the target mRNAs. MiR-133a, as a miRNA, participate in tumorigenesis, progression, autophagy and drug-resistance in various malignancies. Based on the recent insights, we discuss the functions of miR-133a in physiological and pathological processes and its potential effects on cancer diagnosis, prognosis and therapy.
微小RNA（miRNA）可通过与靶mRNA的3'非翻译区（3'-UTR）结合，在转录后水平调控癌症相关基因的表达。MiR-133a作为一种miRNA，参与多种恶性肿瘤的发生、发展、自噬及耐药过程。基于最近的研究进展，我们讨论了MiR-133a在生理和病理过程中的功能及其对癌症诊断、预后和治疗的潜在影响。
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