肾脏癌中的代谢重编程。

Reprogramming of Metabolism in Kidney Cancer.

机构信息

Department of Pathology, University of California, San Diego, La Jolla, CA.

出版信息

Semin Nephrol. 2020 Jan;40(1):2-13. doi: 10.1016/j.semnephrol.2019.12.002.

DOI:10.1016/j.semnephrol.2019.12.002

Abstract

Metabolic reprogramming is one of the major steps that tumor cells take during cancer progression. This process allows the cells to survive in a nutrient- and oxygen-deprived environment, to become stress tolerant, and to metastasize to different sites. Recent studies have shown that reprogramming happens in stromal cells and involves the cross-talk of the cancer cell/tumor microenvironment. There are similarities between the metabolic reprogramming that occurs in both noncancerous kidney diseases and renal cell carcinoma (RCC), suggesting that such reprogramming is a means by which renal epithelial cells survive injury and repair the tissue, and that RCC cells hijack this system. This article reviews reprogramming of major metabolism pathways in RCC, highlighting similarities and differences from kidney diseases and potential therapeutic strategies against it.

摘要

代谢重编程是肿瘤细胞在癌症进展过程中采取的主要步骤之一。这一过程使细胞能够在营养和氧气匮乏的环境中存活，变得耐受应激，并转移到不同的部位。最近的研究表明，重编程发生在基质细胞中，并涉及癌细胞/肿瘤微环境的串扰。在非癌性肾脏疾病和肾细胞癌（RCC）中发生的代谢重编程之间存在相似性，这表明这种重编程是肾上皮细胞在损伤时存活并修复组织的一种方式，而 RCC 细胞则劫持了这一系统。本文综述了 RCC 中主要代谢途径的重编程，强调了与肾脏疾病的相似性和差异性，以及针对这一系统的潜在治疗策略。