癌症疫苗和溶瘤病毒在癌症患者中产生的副作用比其他全身治疗方法要低得多：一项比较分析。
Cancer Vaccines and Oncolytic Viruses Exert Profoundly Lower Side Effects in Cancer Patients than Other Systemic Therapies: A Comparative Analysis.
作者信息
Schirrmacher Volker
机构信息
Immune-Oncological Center Cologne (IOZK), D-50674 Cologne, Germany.
出版信息
Biomedicines. 2020 Mar 16;8(3):61. doi: 10.3390/biomedicines8030061.
Abstract
This review compares cytotoxic drugs, targeted therapies, and immunotherapies with regard to mechanisms and side effects. Targeted therapies relate to small molecule inhibitors. Immunotherapies include checkpoint inhibitory antibodies, chimeric antigen receptor (CAR) T-cells, cancer vaccines, and oncolytic viruses. All these therapeutic approaches fight systemic disease, be it micro-metastatic or metastatic. The analysis includes only studies with a proven therapeutic effect. A clear-cut difference is observed with regard to major adverse events (WHO grades 3-4). Such severe side effects are not observed with cancer vaccines/oncolytic viruses while they are seen with all the other systemic therapies. Reasons for this difference are discussed.
摘要
本综述比较了细胞毒性药物、靶向疗法和免疫疗法在作用机制和副作用方面的差异。靶向疗法涉及小分子抑制剂。免疫疗法包括检查点抑制抗体、嵌合抗原受体（CAR）T细胞、癌症疫苗和溶瘤病毒。所有这些治疗方法都用于对抗全身性疾病，无论是微转移还是转移阶段的疾病。分析仅纳入了具有已证实治疗效果的研究。在主要不良事件（世界卫生组织3 - 4级）方面观察到了明显差异。癌症疫苗/溶瘤病毒未观察到此类严重副作用，而在所有其他全身治疗中则可见到。本文讨论了造成这种差异的原因。
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