睡眠质量与端粒长度的关联：一项对美国老年人的回顾性队列研究。
Association of sleep quality with telomere length, a marker of cellular aging: A retrospective cohort study of older adults in the United States.
机构信息
Department of Pharmaceutical Systems and Policy, West Virginia University School of Pharmacy, Robert C. Byrd Health Sciences Center [North], Morgantown, WV.
Department of Epidemiology, West Virginia University School of Public Health, Morgantown, WV.
出版信息
Sleep Health. 2020 Aug;6(4):513-521. doi: 10.1016/j.sleh.2019.12.003. Epub 2020 Mar 27.
BACKGROUND
Sleep quality is a risk factor for age-related diseases, and although the underlying mechanisms remain unclear, the effects of poor sleep quality on telomere length (TL) may play a role.
OBJECTIVE
The objective of the study was to evaluate the independent association between sleep quality and salivary TL in a large sample of older adults.
DESIGN
We adopted a retrospective cohort design, and participants comprised 5,268 adults drawn from the Health and Retirement Study. We used the 2006 (baseline) and 2008 (follow-up) waves. Baseline sleep quality was assessed using 4 Likert scale questions (trouble falling asleep, waking up during the night, waking up too early and not being able to fall sleep again, and feeling well rested in the morning). The TL was assessed using the T/S ratio, a continuous variable. The associations between sleep quality and T/S were assessed using multivariable ordinary least squares regressions. All analyses were adjusted for demographics, lifestyle characteristics, psychosocial, and other factors.
RESULTS
Overall, 16% reported never feeling well rested in the morning; 25.7% of respondents always had trouble waking during the night; and 12.8% always had trouble waking up too early in the morning. Respondents who never felt rested in the morning had significantly shorter TL than those who always felt rested in the morning (adjusted beta = -0.08, standard error = 0.03, P < .01). The composite sleep measure was not significantly associated with shorter TL.
CONCLUSIONS
In this cohort of older adults, not feeling well rested in the morning was significantly and inversely associated with TL; however, the composite measure of sleep quality was not significantly associated with TL. These findings suggest a potential connection between one of the measures of impaired sleep and reduction in TL, a marker of cellular aging that has been linked to multiple chronic conditions.
背景
睡眠质量是与年龄相关疾病的一个风险因素，尽管其潜在机制尚不清楚，但睡眠质量差对端粒长度（TL）的影响可能起作用。
目的
本研究旨在评估大量老年人中睡眠质量与唾液 TL 之间的独立关联。
设计
我们采用回顾性队列设计，参与者来自健康与退休研究（Health and Retirement Study）的 5268 名成年人。我们使用了 2006 年（基线）和 2008 年（随访）两个时间点。使用 4 个李克特量表问题（入睡困难、夜间醒来、过早醒来且无法再次入睡、早上感觉休息良好）评估基线睡眠质量。使用 T/S 比值评估 TL，这是一个连续变量。使用多变量普通最小二乘回归评估睡眠质量与 T/S 的关联。所有分析均调整了人口统计学、生活方式特征、心理社会和其他因素。
结果
总体而言，16%的人报告说早上从未感觉休息得很好；25.7%的受访者总是在夜间醒来有困难；12.8%的人总是在早上醒来过早有困难。早上从未感觉休息好的受访者 TL 明显短于早上总是感觉休息好的受访者（调整后的β= -0.08，标准误= 0.03，P <.01）。综合睡眠测量指标与较短的 TL 无显著相关性。
结论
在这个老年人群队列中，早上感觉休息不好与 TL 显著负相关；然而，睡眠质量的综合衡量指标与 TL 无显著相关性。这些发现表明，一种衡量睡眠障碍的方法与 TL 降低之间存在潜在联系，TL 是细胞衰老的标志物，与多种慢性疾病有关。
Zotero 插件