开发治疗自身免疫性疾病疗法的挑战、进展与展望。
Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases.
机构信息
Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; Department of Clinical Medicine, Aarhus University Hospital, 8200 N Aarhus, Denmark.
Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; Department of Clinical Medicine, Aarhus University Hospital, 8200 N Aarhus, Denmark.
出版信息
Cell. 2020 Apr 2;181(1):63-80. doi: 10.1016/j.cell.2020.03.007.
Autoimmune diseases are a result of the immune system being misdirected toward its host and have major and increasing unmet clinical needs. In general, present therapies are broadly acting and non-disease specific; consequently, they are associated with numerous side effects. Precise and early intervention strategies are urgently needed. We highlight the challenges, progress, and prospects in achieving these goals.
自身免疫性疾病是免疫系统错误攻击自身的结果，存在重大且日益未满足的临床需求。一般来说，目前的治疗方法作用广泛且非针对特定疾病；因此，它们会引起许多副作用。迫切需要精确和早期的干预策略。我们强调了在实现这些目标方面面临的挑战、取得的进展和前景。
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