磷脂的消防水带。

A firehose for phospholipids.

机构信息

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.

Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA.

出版信息

J Cell Biol. 2020 May 4;219(5). doi: 10.1083/jcb.202003132.

DOI:10.1083/jcb.202003132

PMID:32339216

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7199846/

Abstract

All lipid transport proteins in eukaryotes are thought to shuttle lipids between cellular membranes. In this issue, Li et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202001161) show that Vps13 has a channel-like domain that may allow lipids to flow between closely apposed membranes at contact sites.

摘要

所有真核生物的脂类转运蛋白都被认为在细胞膜之间转运脂类。在本期中，Li 等人（2020. J. Cell Biol. https://doi.org/10.1083/jcb.202001161）表明 Vps13 具有一个类似通道的结构域，这可能允许脂质在紧密相邻的接触部位的膜之间流动。