罗塞塔中的大分子建模和设计：最新方法和框架。
Macromolecular modeling and design in Rosetta: recent methods and frameworks.
机构信息
Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY, USA.
Department of Biology, New York University, New York, New York, USA.
出版信息
Nat Methods. 2020 Jul;17(7):665-680. doi: 10.1038/s41592-020-0848-2. Epub 2020 Jun 1.
Abstract
The Rosetta software for macromolecular modeling, docking and design is extensively used in laboratories worldwide. During two decades of development by a community of laboratories at more than 60 institutions, Rosetta has been continuously refactored and extended. Its advantages are its performance and interoperability between broad modeling capabilities. Here we review tools developed in the last 5 years, including over 80 methods. We discuss improvements to the score function, user interfaces and usability. Rosetta is available at http://www.rosettacommons.org.
摘要
罗塞塔软件（Rosetta software）是一款用于大分子建模、对接和设计的软件，在全球范围内的实验室中得到广泛应用。在过去的 20 年中，由 60 多个机构的实验室社区不断地进行重构和扩展，罗塞塔软件得到了持续的发展。它的优势在于其性能和广泛建模能力之间的互操作性。在这里，我们回顾了过去 5 年中开发的工具，包括 80 多种方法。我们讨论了对评分函数、用户界面和可用性的改进。罗塞塔软件可在 http://www.rosettacommons.org 获取。
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