自噬与阿尔茨海默病。

Autophagy and Alzheimer's Disease.

机构信息

Department of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Liaoning Provincial Center for Clinical Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China.

出版信息

Adv Exp Med Biol. 2020;1207:3-19. doi: 10.1007/978-981-15-4272-5_1.

DOI:10.1007/978-981-15-4272-5_1

PMID:32671736

Abstract

Alzheimer's disease (AD) is the most common type of dementia and is characterized by progressive cognitive decline. Increasing evidence has demonstrated that the autophagic process plays an important role in AD. In this chapter, we will discuss the role of autophagy in the pathogenesis of AD and other types of dementia, including dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), vascular dementia (VD) and prion diseases. In addition, we will discuss autophagy-targeted therapies as future treatments for AD.

摘要

阿尔茨海默病（AD）是最常见的痴呆类型，其特征是进行性认知能力下降。越来越多的证据表明，自噬过程在 AD 中起着重要作用。在本章中，我们将讨论自噬在 AD 及其他类型痴呆（包括路易体痴呆（DLB）、额颞叶痴呆（FTD）、血管性痴呆（VD）和朊病毒病）发病机制中的作用。此外，我们还将讨论针对自噬的治疗方法作为 AD 的未来治疗方法。