婚姻状况对脊索瘤成年患者总生存的影响：一项基于 SEER 的研究。

Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study.

机构信息

Pain Department, Pizhou City People's Hospital, Xuzhou Medical University, Xuzhou City, 200032, Jiangsu Province, China.

Nursing Department, Xijing Hospital, Air Force Medical University, Xi'an City, 710032, Shanxi Province, China.

出版信息

J Orthop Surg Res. 2020 Jul 23;15(1):278. doi: 10.1186/s13018-020-01803-6.

DOI:10.1186/s13018-020-01803-6

PMID:32703313

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7376721/

Abstract

BACKGROUND

As a rare primary bone tumor, no studies have reported the relationship between prognosis and marital status in patients with chordoma.

METHODS

We classified patients with chordoma identified from the Surveillance, Epidemiology, and End Results (SEER) database from 1975 to 2016 into four groups: married, divorced/separated, widowed, and single groups. Kaplan-Meier curves with log-rank test and Cox regression were used to analyze the effect of marital status on overall survival (OS).

RESULTS

A total of 1080 patients were included in the study: 700 (64.8%) were married, 88 (8.1%) were divorced/separated, 78 (7.2%) were widowed, and 214 (19.8%) were single. Among the 4 groups, the 5-year OS (45.2%), 10-year OS (12.5%), and median OS (56.0 months) were the lowest in the widowed group. After including age, sex, primary site, marital status, disease stage, tumor size, histological type, and treatment pattern, multivariate analysis showed that marital status was still an independent risk factor for patients with chordoma, and widowed patients had the lowest OS (hazard ratio [HR] 1.71; 95% confidence interval [CI] 1.25-2.33, p < 0.001) compared with married patients. Similar results were observed after stratifying the primary site and disease stage.

CONCLUSION

Marital status was an independent prognostic indicator for adult patients with chordoma, and marital status was conducive to patient survival. Compared with married patients, widowed patients have a higher risk of death.

摘要

背景

作为一种罕见的原发性骨肿瘤，目前尚无研究报道 chordoma 患者的预后与婚姻状况之间的关系。

方法

我们将 1975 年至 2016 年期间从 Surveillance, Epidemiology, and End Results（SEER）数据库中确定的 chordoma 患者分为四组：已婚组、离婚/分居组、丧偶组和单身组。使用 Kaplan-Meier 曲线和对数秩检验以及 Cox 回归分析婚姻状况对总生存期（OS）的影响。

结果

本研究共纳入 1080 例患者：已婚 700 例（64.8%），离婚/分居 88 例（8.1%），丧偶 78 例（7.2%），单身 214 例（19.8%）。在这 4 组中，丧偶组的 5 年 OS（45.2%）、10 年 OS（12.5%）和中位 OS（56.0 个月）最低。在纳入年龄、性别、原发部位、婚姻状况、疾病分期、肿瘤大小、组织学类型和治疗方式后，多因素分析显示婚姻状况仍是 chordoma 患者的独立危险因素，丧偶患者的 OS 最低（风险比[HR]1.71；95%置信区间[CI]1.25-2.33，p<0.001），与已婚患者相比。在分层原发部位和疾病分期后也观察到了相似的结果。