早期前体T细胞急性淋巴细胞白血病：当前范式与不断演变的概念
Early precursor T-cell acute lymphoblastic leukemia: current paradigms and evolving concepts.
作者信息
Castaneda Puglianini Omar, Papadantonakis Nikolaos
机构信息
Virginia Commonwealth University, Massey Cancer Center, Cellular Immunotherapies and Transplant Program, Richmond, Virginia, USA.
Department of Hematology and Medical Oncology, Emory University, 1365 Clifton Road, Building B, B4119, Atlanta, Georgia, USA.
出版信息
Ther Adv Hematol. 2020 Jul 16;11:2040620720929475. doi: 10.1177/2040620720929475. eCollection 2020.
Abstract
Early precursor T cell-acute lymphoblastic leukemia (ETP-ALL) is a rare entity characterized by chemo-resistance and a paucity of data regarding optimal management. We review here the literature regarding the management of ETP-ALL and focus on the recent, emerging data, regarding the potential role of molecularly targeted approaches with a focus on venetoclax.
摘要
早期前体T细胞急性淋巴细胞白血病（ETP-ALL）是一种罕见的疾病，其特征为化疗耐药且关于最佳治疗方案的数据匮乏。我们在此回顾关于ETP-ALL治疗的文献，并重点关注近期出现的、关于分子靶向治疗方法潜在作用的数据，尤其关注维奈克拉。
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