Department of Anesthesiology, Harvard Medical School, Brigham & Women's Hospital, Boston, Massachusetts.
Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Pain Med. 2020 Oct 1;21(10):2336-2347. doi: 10.1093/pm/pnaa192.
Recent studies suggest that sensory phenotyping may provide critical information for the diagnosis and management of patients with chronic neuropathic pain (NP). However, many formal quantitative sensory testing (QST) paradigms require expensive equipment, a dedicated location, and substantial time commitments on the part of patient and examiner, highlighting the need for a convenient and portable "bedside" QST battery. We developed and tested a bedside QST battery in a sample of patients with chronic NP.
Participants (N = 51) attended two in-person visits over approximately two weeks, during which they underwent QST using both laboratory-based equipment and simple, easily accessible bedside tools. Participants also completed questionnaires about their daily pain and NP symptoms.
Test-retest reliability estimates were highly statistically significant and did not differ between bedside (mean r = 0.60) and laboratory-based (mean r = 0.72) QST. Bedside QST variables and corresponding laboratory-based QST variables were highly correlated, suggesting adequate criterion validity for the bedside tests.
Results from the present study may have important implications for the sensory phenotyping and subsequent management of patients with chronic NP. Implementation of a protocol that uses inexpensive, portable, and convenient tools may allow for the application of QST in variety of clinical settings and advance NP research.
最近的研究表明,感觉表型分析可为慢性神经性疼痛(NP)患者的诊断和治疗提供重要信息。然而,许多正式的定量感觉测试(QST)范式需要昂贵的设备、专门的地点和患者及检查者大量的时间投入,这凸显出需要一种方便且便携的“床边”QST 电池。我们在慢性 NP 患者样本中开发并测试了一种床边 QST 电池。
参与者(N=51)在大约两周的时间内参加了两次现场访问,在此期间,他们使用实验室设备和简单、易于获取的床边工具进行了 QST。参与者还完成了关于日常疼痛和 NP 症状的问卷。
测试-重测可靠性估计值具有高度统计学意义,且床边(平均 r=0.60)和实验室(平均 r=0.72)QST 之间无差异。床边 QST 变量与相应的实验室 QST 变量高度相关,表明床边测试具有足够的标准有效性。
本研究的结果可能对慢性 NP 患者的感觉表型分析和随后的管理具有重要意义。实施使用廉价、便携和方便工具的方案可能允许在各种临床环境中应用 QST,并推进 NP 研究。