糖酵解失败作为痴呆的最后共同途径。
Glymphatic failure as a final common pathway to dementia.
机构信息
Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
出版信息
Science. 2020 Oct 2;370(6512):50-56. doi: 10.1126/science.abb8739.
Sleep is evolutionarily conserved across all species, and impaired sleep is a common trait of the diseased brain. Sleep quality decreases as we age, and disruption of the regular sleep architecture is a frequent antecedent to the onset of dementia in neurodegenerative diseases. The glymphatic system, which clears the brain of protein waste products, is mostly active during sleep. Yet the glymphatic system degrades with age, suggesting a causal relationship between sleep disturbance and symptomatic progression in the neurodegenerative dementias. The ties that bind sleep, aging, glymphatic clearance, and protein aggregation have shed new light on the pathogenesis of a broad range of neurodegenerative diseases, for which glymphatic failure may constitute a therapeutically targetable final common pathway.
睡眠在所有物种中都是进化保守的，而睡眠受损是疾病大脑的共同特征。随着年龄的增长，睡眠质量会下降，而正常睡眠结构的破坏是神经退行性疾病痴呆发病的常见前兆。脑淋巴系统清除大脑中的蛋白质废物，主要在睡眠时活跃。然而，脑淋巴系统随着年龄的增长而退化，这表明睡眠障碍与神经退行性痴呆症的症状进展之间存在因果关系。睡眠、衰老、脑淋巴清除和蛋白质聚集之间的联系为广泛的神经退行性疾病的发病机制提供了新的线索，对于这些疾病，脑淋巴功能衰竭可能构成一种可治疗的靶向共同途径。
Zotero 插件