潜伏性弓形体病与抑郁和自杀行为有关。

Latent Toxoplasmosis is Associated with Depression and Suicidal Behavior.

出版信息

Arch Suicide Res. 2022 Apr-Jun;26(2):819-830. doi: 10.1080/13811118.2020.1838368. Epub 2020 Nov 9.

DOI:10.1080/13811118.2020.1838368

Abstract

OBJECTIVE

Neuroinflammation is implicated in the pathophysiology of depression. () causes chronic brain inflammatory process and may thus contribute to both depression and its most serious complication, suicidal behavior. In this study, we hypothesized that latent toxoplasmosis may underlie current depression and/or suicidal behavior.

METHOD

Currently depressed individuals ( = 384) and age, sex, and residence-matched healthy controls (HC) ( = 400) were tested for latent toxoplasmosis (i.e., positive serum IgG antibodies). Exclusions included positive IgM and negative IgG antibodies indicating acute infection and history of cognitive problems. Depression severity and history of lifetime suicide attempts were assessed using Beck Depression Inventory (BDI) and Columbia Suicide Severity Rating Scale, respectively.

RESULTS

Participants with seropositive anti- IgG antibody had a significantly higher odds of being depressed compared with seronegative participants (OR = 2.9, 95% CI: 1.9-4.3; < 0.001). BDI score was significantly different between depressed seropositive and depressed seronegative individuals (IgG＋: mean (SD)= 39.65 (11.83) . IgG-: mean (SD)= 33.44(9.80); t = 5.03, < 0.001). Further, seropositive depressed participants were more likely to have prior history of actual suicide attempts compared with seronegative participants (OR= 6.2, 95% CI: 3.4-11.2, < 0.001).

CONCLUSIONS

Latent toxoplasmosis may represent be a risk factor for depression and suicidal behavior. Screening for, and treatment of, underlying infection may help improve depression and curb the increasing suicide rates. Future studies should prospectively test these hypotheses to be adequately implemented.HIGHLIGHTSLatent toxoplasmosis has been linked to history of psychiatric disorders.Depressed individuals have higher positivity rate of IgG antibody than healthy controls.Depressed seropositive individuals have increased likelihood to have history of suicidal behavior.

摘要

目的

神经炎症与抑郁症的病理生理学有关。（）导致慢性大脑炎症过程，因此可能导致抑郁和最严重的并发症，自杀行为。在这项研究中，我们假设潜伏性弓形体病可能是当前抑郁和/或自杀行为的基础。

方法

目前患有抑郁症的个体（n=384）和年龄、性别和居住地匹配的健康对照组（HC）（n=400）接受了潜伏性弓形体病（即血清 IgG 抗体阳性）的检测。排除标准包括阳性 IgM 和阴性 IgG 抗体，提示急性感染和认知问题史。使用贝克抑郁量表（BDI）和哥伦比亚自杀严重程度评定量表分别评估抑郁严重程度和终生自杀尝试史。

结果

与血清 IgG 阴性者相比，血清 IgG 抗体阳性者患抑郁症的可能性显著更高（OR=2.9，95%CI：1.9-4.3；<0.001）。BDI 评分在抑郁 IgG 阳性和抑郁 IgG 阴性个体之间存在显著差异（IgG＋：平均值（SD）=39.65（11.83），IgG-：平均值（SD）=33.44（9.80）；t=5.03，<0.001）。此外，与血清 IgG 阴性的抑郁患者相比，血清 IgG 阳性的抑郁患者有过实际自杀尝试的既往史的可能性更高（OR=6.2，95%CI：3.4-11.2，<0.001）。