哺乳动物 Argonaute2 功能的新见解。
New insights into the function of mammalian Argonaute2.
机构信息
University of Silesia in Katowice, Faculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, Katowice, Poland.
出版信息
PLoS Genet. 2020 Nov 12;16(11):e1009058. doi: 10.1371/journal.pgen.1009058. eCollection 2020 Nov.
Uncovering the mechanisms that recognise a microRNA (miRNA) target is 1 of the biggest challenges because the Ago-miRNA complex is able to overcome different derogations of complementarity when binding targets. However, the recently solved crystallographic structure of Argonaute2 (Ago2) and a high-throughput analysis that used repurposed sequencing techniques has brought us closer to achieving this goal.
揭示识别 microRNA（miRNA）靶标的机制是最大的挑战之一，因为 Ago-miRNA 复合物在结合靶标时能够克服不同程度的互补性偏差。然而，最近解析的 Argonaute2（Ago2）晶体结构和使用重新利用测序技术的高通量分析使我们更接近实现这一目标。
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