儿童焦虑障碍中的巴甫洛夫式学习过程：批判性评价。
Pavlovian Learning Processes in Pediatric Anxiety Disorders: A Critical Review.
机构信息
Department of Psychology, University of California, Los Angeles, Los Angeles, California.
Department of Psychology, University of California, Los Angeles, Los Angeles, California; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California.
出版信息
Biol Psychiatry. 2021 Apr 1;89(7):690-696. doi: 10.1016/j.biopsych.2020.09.008. Epub 2020 Sep 12.
Abstract
Deficits in associative and Pavlovian learning are thought to lie at the center of anxiety-related disorders. However, the majority of studies have been carried out in adult populations. The aim of this review was to critically examine the behavioral and neuroimaging literature on Pavlovian learning in pediatric anxiety disorders. We conclude that although there is evidence for deficits in Pavlovian processes (e.g., heightened reactivity to safety cues in anxious samples), the extant literature suffers from key methodological and theoretical issues. We conclude with theoretical and methodological recommendations for future research in order to further elucidate the role of Pavlovian learning in the etiology, maintenance, and treatment of pediatric anxiety disorders.
摘要
关联学习和巴甫洛夫学习缺陷被认为是焦虑相关障碍的核心。然而，大多数研究都是在成年人群中进行的。本综述的目的是批判性地检查儿童焦虑障碍的巴甫洛夫学习的行为和神经影像学文献。我们的结论是，尽管有证据表明巴甫洛夫过程存在缺陷（例如，焦虑样本对安全线索的反应增强），但现有文献存在关键的方法学和理论问题。我们最后提出了理论和方法学建议，以供未来的研究进一步阐明巴甫洛夫学习在儿童焦虑障碍的病因、维持和治疗中的作用。
相似文献
1
Pavlovian Learning Processes in Pediatric Anxiety Disorders: A Critical Review.
Biol Psychiatry. 2021 Apr 1;89(7):690-696. doi: 10.1016/j.biopsych.2020.09.008. Epub 2020 Sep 12.
2
The role of associative fear and avoidance learning in anxiety disorders: Gaps and directions for future research.
Neurosci Biobehav Rev. 2018 May;88:117-140. doi: 10.1016/j.neubiorev.2018.03.015. Epub 2018 Mar 14.
3
Fear conditioning and extinction in anxious and non-anxious youth: A meta-analysis.
Behav Res Ther. 2019 Sep;120:103431. doi: 10.1016/j.brat.2019.103431. Epub 2019 Jun 20.
4
Safety learning and the Pavlovian conditioned inhibition of fear in humans: Current state and future directions.
Neurosci Biobehav Rev. 2021 Aug;127:659-674. doi: 10.1016/j.neubiorev.2021.05.014. Epub 2021 May 21.
5
Fear conditioning and extinction in anxious and nonanxious youth and adults: examining a novel developmentally appropriate fear-conditioning task.
Depress Anxiety. 2015 Apr;32(4):277-88. doi: 10.1002/da.22318. Epub 2014 Nov 27.
6
Aversive Pavlovian conditioning in childhood anxiety disorders: impaired response inhibition and resistance to extinction.
J Abnorm Psychol. 2009 May;118(2):311-21. doi: 10.1037/a0015635.
7
White matter correlates of contextual pavlovian fear extinction and the role of anxiety in healthy humans.
Cortex. 2019 Dec;121:179-188. doi: 10.1016/j.cortex.2019.08.020. Epub 2019 Sep 20.
8
Distraction/Suppression and Distress Endurance diminish the extent to which generalized conditioned fear is associated with maladaptive behavioral avoidance.
Behav Res Ther. 2017 Sep;96:90-105. doi: 10.1016/j.brat.2017.04.013. Epub 2017 Apr 27.
9
Anxiety sensitivity and intolerance of uncertainty facilitate associations between generalized Pavlovian fear and maladaptive avoidance decisions.
J Abnorm Psychol. 2019 May;128(4):315-326. doi: 10.1037/abn0000422. Epub 2019 Mar 4.
10
Maladaptive behavioral consequences of conditioned fear-generalization: a pronounced, yet sparsely studied, feature of anxiety pathology.
Behav Res Ther. 2014 Jun;57:29-37. doi: 10.1016/j.brat.2014.03.009. Epub 2014 Apr 3.
引用本文的文献
1
Puberty, sex, and fear extinction retention: A neuroimaging study in youth.
Dev Cogn Neurosci. 2025 Jul 7;75:101595. doi: 10.1016/j.dcn.2025.101595.
2
Developmental differences in threat learning are associated with changes in frontal-central theta activity.
Eur Child Adolesc Psychiatry. 2025 May 27. doi: 10.1007/s00787-025-02745-2.
3
Trait self-compassion enhances activation in the medial prefrontal cortex during fear extinction: An fNIRS study.
Int J Clin Health Psychol. 2024 Oct-Dec;24(4):100516. doi: 10.1016/j.ijchp.2024.100516. Epub 2024 Nov 6.
4
Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology.
Dev Psychopathol. 2024 Sep 26:1-13. doi: 10.1017/S095457942400141X.
5
Extinction Learning Across Development: Neurodevelopmental Changes and Implications for Pediatric Anxiety Disorders.
Curr Top Behav Neurosci. 2023;64:237-256. doi: 10.1007/7854_2023_430.
6
Unconditioned and conditioned anxiolytic effects of Sodium Valproate on flavor neophobia and fear conditioning.
PLoS One. 2023 Jul 7;18(7):e0279511. doi: 10.1371/journal.pone.0279511. eCollection 2023.
7
Fear-potentiated startle reveals diminished threat extinction in pathological anxiety.
Int J Psychophysiol. 2023 Jan;183:81-91. doi: 10.1016/j.ijpsycho.2022.11.011. Epub 2022 Nov 25.
8
Safety learning during development: Implications for development of psychopathology.
Behav Brain Res. 2021 Jun 25;408:113297. doi: 10.1016/j.bbr.2021.113297. Epub 2021 Apr 18.
本文引用的文献
1
Age Differences in the Neural Correlates of Anxiety Disorders: An fMRI Study of Response to Learned Threat.
Am J Psychiatry. 2020 May 1;177(5):454-463. doi: 10.1176/appi.ajp.2019.19060650. Epub 2020 Apr 7.
2
The neural and computational systems of social learning.
Nat Rev Neurosci. 2020 Apr;21(4):197-212. doi: 10.1038/s41583-020-0276-4. Epub 2020 Mar 12.
3
Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure.
Biol Psychiatry. 2020 May 15;87(10):916-925. doi: 10.1016/j.biopsych.2019.11.006. Epub 2019 Nov 15.
4
Mechanisms of systems memory consolidation during sleep.
Nat Neurosci. 2019 Oct;22(10):1598-1610. doi: 10.1038/s41593-019-0467-3. Epub 2019 Aug 26.
5
Fear conditioning and extinction in anxious youth, offspring at-risk for anxiety and healthy comparisons: An fMRI study.
Biol Psychol. 2019 Nov;148:107744. doi: 10.1016/j.biopsycho.2019.107744. Epub 2019 Aug 23.
6
Neural responses during extinction learning predict exposure therapy outcome in phobia: results from a randomized-controlled trial.
Neuropsychopharmacology. 2020 Feb;45(3):534-541. doi: 10.1038/s41386-019-0467-8. Epub 2019 Jul 28.
7
Fear conditioning and extinction in anxious and non-anxious youth: A meta-analysis.
Behav Res Ther. 2019 Sep;120:103431. doi: 10.1016/j.brat.2019.103431. Epub 2019 Jun 20.
8
Threat-related disorders as persistent motivational states of defense.
Curr Opin Behav Sci. 2019 Apr;26:62-68. doi: 10.1016/j.cobeha.2018.10.007. Epub 2018 Oct 25.
9
Occasion setting.
Behav Neurosci. 2019 Apr;133(2):145-175. doi: 10.1037/bne0000306.
10
Fear extinction learning as a predictor of response to cognitive behavioral therapy for pediatric obsessive compulsive disorder.
J Anxiety Disord. 2019 May;64:1-8. doi: 10.1016/j.janxdis.2019.02.005. Epub 2019 Mar 1.
Zotero 插件