Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang), Zhanjiang, China.
Department of Family Medicine and Public Health, School of Medicine, University of California San Diego, CA 92093, USA.
Biomed Pharmacother. 2021 Jan;133:111007. doi: 10.1016/j.biopha.2020.111007. Epub 2020 Nov 20.
CRISPR gene editing technology belongs to the third generation of gene editing technology. Since its discovery, it has attracted the attention of a large number of researchers. Investigators have published a series of academic articles and obtained breakthrough research results through in-depth research. In recent years, this technology has developed rapidly and been widely applied in many fields, especially in medicine. This review focuses on concepts of CRISPR gene editing technology, its application in cancer treatments, its existing limitations, and the new progress in recent years for detailed analysis and sharing.
CRISPR 基因编辑技术属于第三代基因编辑技术。自发现以来,它吸引了大量研究人员的关注。研究人员发表了一系列学术文章,并通过深入研究取得了突破性的研究成果。近年来,这项技术发展迅速,广泛应用于许多领域,特别是医学领域。本文详细分析和分享了 CRISPR 基因编辑技术的概念、在癌症治疗中的应用、目前存在的局限性以及近年来的新进展。