脂蛋白脂肪酶及其调控因子：一个正在展开的故事。
Lipoprotein Lipase and Its Regulators: An Unfolding Story.
机构信息
Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI48105, USA.
Nutrition Metabolism and Genomics group, Wageningen University, Wageningen, The Netherlands.
出版信息
Trends Endocrinol Metab. 2021 Jan;32(1):48-61. doi: 10.1016/j.tem.2020.11.005. Epub 2020 Dec 1.
Abstract
Lipoprotein lipase (LPL) is one of the most important factors in systemic lipid partitioning and metabolism. It mediates intravascular hydrolysis of triglycerides packed in lipoproteins such as chylomicrons and very-low-density lipoprotein (VLDL). Since its initial discovery in the 1940s, its biology and pathophysiological significance have been well characterized. Nonetheless, several studies in the past decade, with recent delineation of LPL crystal structure and the discovery of several new regulators such as angiopoietin-like proteins (ANGPTLs), glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), lipase maturation factor 1 (LMF1) and Sel-1 suppressor of Lin-12-like 1 (SEL1L), have completely transformed our understanding of LPL biology.
摘要
脂蛋白脂肪酶（LPL）是全身脂质分配和代谢的最重要因素之一。它介导脂蛋白（如乳糜微粒和极低密度脂蛋白（VLDL））中包裹的甘油三酯的血管内水解。自 20 世纪 40 年代首次发现以来，其生物学和病理生理学意义已得到很好的描述。尽管如此，过去十年的几项研究，最近对 LPL 晶体结构的描绘以及发现了几种新的调节剂，如血管生成素样蛋白（ANGPTLs）、糖基磷脂酰肌醇锚定的高密度脂蛋白结合蛋白 1（GPIHBP1）、脂肪酶成熟因子 1（LMF1）和 Sel-1 Lin-12 样抑制因子 1（SEL1L），彻底改变了我们对 LPL 生物学的理解。
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