68Ga-FAPI PET/CT 与 68Ga-DOTATATE PET/CT 评估神经内分泌肿瘤患者的比较。
68Ga-FAPI PET/CT Versus 68Ga-DOTATATE PET/CT in the Evaluation of a Patient With Neuroendocrine Tumor.
机构信息
From the Department of Nuclear Medicine, Gazi Yaşargil Training and Research Hospital, University of Health Sciences, Diyarbakir, Turkey.
出版信息
Clin Nucl Med. 2021 May 1;46(5):e290-e292. doi: 10.1097/RLU.0000000000003490.
68Ga-FAPI (fibroblast activation protein-specific inhibitor) PET/CT was performed in a 56-year-old man with multiple liver masses, which were confirmed grade 2 well-differentiated neuroendocrine tumors with liver Tru-Cut biopsy. With 68Ga-DOTATE PET/CT, primary tumor in the pancreas, multiple metastases in the liver and metastatic portocaval lymph node were detected. In 68Ga-FAPI PET/CT imaging performed for comparison, it was seen that metastatic lesions in the liver were distinguished much better because of low background activity, and the primary tumor and metastatic lymph node were clearly selected. This case suggested that FAPI-bounded radionuclides may be useful in the evaluation and targeted therapy of neuroendocrine tumors.
68Ga-FAPI（成纤维细胞激活蛋白特异性抑制剂）PET/CT 检查用于一位 56 岁的男性，他有多发性肝肿块，肝 Tru-Cut 活检证实为 2 级分化良好的神经内分泌肿瘤。68Ga-DOTATE PET/CT 检查发现胰腺原发肿瘤、肝脏多处转移和门腔转移淋巴结。比较 68Ga-FAPI PET/CT 成像，由于背景活性低，肝转移灶的区分度明显更好，原发肿瘤和转移淋巴结也能清晰显示。该病例提示 FAPI 结合放射性核素可能对神经内分泌肿瘤的评估和靶向治疗有用。
Zotero 插件