囊性纤维化患儿肺清除指数异常，但 FEV1 和单次呼吸氮清除试验正常。
Abnormal Lung Clearance Index in Cystic Fibrosis Children with Normal FEV and Single-Breath Nitrogen Washout Test.
机构信息
Division of Pediatric Pulmonology, Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Emory University, Atlanta, GA, USA.
出版信息
Lung. 2021 Feb;199(1):37-41. doi: 10.1007/s00408-020-00412-8. Epub 2021 Jan 3.
Single- and multiple-breath washout tests (SBW and MBW) measure ventilation inhomogeneity, but the relationship between them is unclear. Forty-three subjects with cystic fibrosis (CF) and healthy controls (HC) 8-21 years of age were recruited (CF = 30 and HC = 13) and performed nitrogen MBW, vital capacity SBW, spirometry, and plethysmography. Mean phase III slope from SBW (SIII) and lung clearance index (LCI) were significantly different between CF and HC (p = 0.017 and p < 0.0001, respectively). Based on Pearson correlation, SIII and LCI showed strong correlation (ρ = 0.81, p < 0.0001). Both SIII and LCI significantly correlated with spirometry (all p < 0.05). Among CF subjects with normal FEV (≥ 80%; n = 17), 76% (n = 13) had normal SIII but abnormal LCI. We conclude that LCI can be abnormal despite normal SIII and FEV in CF children. Although LCI and SIII showed strong correlation, our results suggest that LCI is a better test to detect ventilation inhomogeneity in CF children with normal FEV.
单呼吸和多呼吸洗脱试验（SBW 和 MBW）可测量通气不均一性，但两者之间的关系尚不清楚。本研究招募了 43 名囊性纤维化（CF）患者和健康对照者（HC）（CF=30，HC=13），进行了氮气 MBW、肺活量 SBW、肺量计检查和体描法检查。SBW 的平均相位 III 斜率（SIII）和肺清除指数（LCI）在 CF 和 HC 之间有显著差异（p=0.017 和 p<0.0001）。基于 Pearson 相关分析，SIII 和 LCI 呈强相关（ρ=0.81，p<0.0001）。SIII 和 LCI 与肺量计检查均显著相关（均 p<0.05）。在 FEV（≥80%）正常的 CF 患者中（n=17），76%（n=13）的 SIII 正常，但 LCI 异常。我们的结论是，在 CF 儿童中，即使 SIII 和 FEV 正常，LCI 也可能异常。尽管 LCI 和 SIII 之间存在很强的相关性，但我们的结果表明，LCI 是检测 FEV 正常的 CF 儿童通气不均一性的更好试验。
Zotero 插件