癌症中的炎症细胞因子：基因治疗的全面理解和临床进展。
Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy.
机构信息
Laboratory of Aging Research and Cancer Drug Target, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China.
State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China.
出版信息
Cells. 2021 Jan 8;10(1):100. doi: 10.3390/cells10010100.
The relationship between chronic inflammation and neoplastic diseases is not fully understood. The inflammatory microenvironment of a tumor is an intricate network that consists of numerous types of cells, cytokines, enzymes and signaling pathways. Recent evidence shows that the crucial components of cancer-related inflammation are involved in a coordinated system to influence the development of cancer, which may shed light on the development of potential anticancer therapies. Since the last century, considerable effort has been devoted to developing gene therapies for life-threatening diseases. When it comes to modulating the inflammatory microenvironment for cancer therapy, inflammatory cytokines are the most efficient targets. In this manuscript, we provide a comprehensive review of the relationship between inflammation and cancer development, especially focusing on inflammatory cytokines. We also summarize the clinical trials for gene therapy targeting inflammatory cytokines for cancer treatment. Future perspectives concerned with new gene-editing technology and novel gene delivery systems are finally provided.
慢性炎症与肿瘤性疾病之间的关系尚未完全阐明。肿瘤的炎症微环境是一个复杂的网络，由多种类型的细胞、细胞因子、酶和信号通路组成。最近的证据表明，与癌症相关的炎症的关键成分参与了一个协调的系统，以影响癌症的发展，这可能为开发潜在的抗癌疗法提供线索。自上个世纪以来，人们投入了大量精力来开发危及生命的疾病的基因疗法。在调节癌症治疗的炎症微环境方面，炎症细胞因子是最有效的靶点。在本文中，我们全面综述了炎症与癌症发展之间的关系，特别是重点关注炎症细胞因子。我们还总结了针对癌症治疗的炎症细胞因子的基因治疗的临床试验。最后还提供了对新的基因编辑技术和新型基因传递系统的未来展望。
Zotero 插件