端粒：历史、健康与衰老的标志。
Telomeres: history, health, and hallmarks of aging.
机构信息
Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
Cell. 2021 Jan 21;184(2):306-322. doi: 10.1016/j.cell.2020.12.028. Epub 2021 Jan 14.
The escalating social and economic burden of an aging world population has placed aging research at center stage. The hallmarks of aging comprise diverse molecular mechanisms and cellular systems that are interrelated and act in concert to drive the aging process. Here, through the lens of telomere biology, we examine how telomere dysfunction may amplify or drive molecular biological processes underlying each hallmark of aging and contribute to development of age-related diseases such as neurodegeneration and cancer. The intimate link of telomeres to aging hallmarks informs preventive and therapeutic interventions designed to attenuate aging itself and reduce the incidence of age-associated diseases.
不断加剧的世界人口老龄化所带来的社会和经济负担，使老龄化研究成为焦点。衰老的特征包括多种相互关联并协同作用的分子机制和细胞系统，这些机制和系统共同推动衰老过程。在这里，我们通过端粒生物学的视角，研究端粒功能障碍如何放大或驱动衰老特征的分子生物学过程，并导致与衰老相关的疾病（如神经退行性疾病和癌症）的发展。端粒与衰老特征的密切联系为预防和治疗干预措施提供了信息，这些干预措施旨在减缓衰老本身并降低与年龄相关的疾病的发病率。
Zotero 插件