嗜碱性粒细胞为湿疹瘙痒火上浇油。
Basophils add fuel to the flame of eczema itch.
机构信息
Department of Molecular and Cell Biology, UC Berkeley, Berkeley, CA, USA; Hellen Wills Neuroscience Institute, UC Berkeley, Berkeley, CA, USA.
Department of Molecular and Cell Biology, UC Berkeley, Berkeley, CA, USA; Hellen Wills Neuroscience Institute, UC Berkeley, Berkeley, CA, USA.
出版信息
Cell. 2021 Jan 21;184(2):294-296. doi: 10.1016/j.cell.2020.12.035.
Children and adults with atopic dermatitis suffer from intractable chronic itch and can also experience acute itch flare ups that significantly increase itch intensity. In this issue of Cell, Wang et al. demonstrate that a subset of basophils activates sensory neurons to drive allergen-evoked itch flare ups in atopic dermatitis.
患有特应性皮炎的儿童和成人都会遭受难以忍受的慢性瘙痒，并且还可能经历急性瘙痒发作，其瘙痒强度会显著增加。在本期《Cell》杂志上，Wang 等人证明了一组嗜碱性粒细胞激活感觉神经元，从而引发特应性皮炎中的变应原诱发的瘙痒发作。
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