CAR 对 COVID-19 肺炎患者住院死亡率的预测价值：一项回顾性队列研究。
Predictive Value of CAR for In-Hospital Mortality in Patients with COVID-19 Pneumonia: A Retrospective Cohort Study.
机构信息
Health Science University, Sultan II. Abdülhamid Han Training and Research Hospital, Department of Internal Medicine, Istanbul, Turkey.
Health Science University, Sultan II. Abdülhamid Han Training and Research Hospital, Department of Internal Medicine, Istanbul, Turkey; Health Science University, Fatih Sultan Mehmet Training and Research Hospital, Department of Internal Medicine, Istanbul, Turkey.
出版信息
Arch Med Res. 2021 Jul;52(5):554-560. doi: 10.1016/j.arcmed.2021.02.006. Epub 2021 Feb 10.
BACKGROUND
In the current literature, there is a growing evidence that supports the significant role of inflammation in the progression of viral pneumonia, including patients with coronavirus disease 2019 (COVID-19).
AIM
The present study aimed to investigate the predictive value of C-reactive protein/albumin ratio (CAR) for in-hospital mortality in patients with COVID-19.
MATERIAL AND METHODS
This retrospective study included the data of 275 consecutive COVID-19 patients who were hospitalized in a referral pandemic center. The CAR ratio was obtained by dividing the CRP level with albumin level. The study population was divided into tertiles (T1, T2, and T3) according to their admission CAR values. The endpoint of the study was a composite outcome of in-hospital mortality.
RESULTS
During the in-hospital course, 33 (12%) patients died. The patients classified into T3 group had significantly higher CAR compared those classified into T2 and T1 groups. After the adjustment for the confounders, T3 group had 8.2 (95% CI: 4.2-48.1) times higher rates of in-hospital mortality compared to T1 group (the reference group) in a logistic regression model using CAR values.
CONCLUSION
To the best of our knowledge, this is the first study to demonstrate the predictive value of CAR for in-hospital mortality in COVID-19 patients.
背景
目前的文献中有越来越多的证据表明炎症在病毒性肺炎的进展中起着重要作用，包括 2019 年冠状病毒病（COVID-19）患者。
目的
本研究旨在探讨 C 反应蛋白/白蛋白比值（CAR）对 COVID-19 患者住院死亡率的预测价值。
材料和方法
这是一项回顾性研究，纳入了 275 例连续 COVID-19 住院患者的数据，这些患者均在一个指定的大流行中心住院。CAR 比值通过将 CRP 水平除以白蛋白水平获得。根据入院时的 CAR 值，将研究人群分为三分位（T1、T2 和 T3）。研究的终点是住院死亡率的复合结局。
结果
在住院期间，有 33 名（12%）患者死亡。T3 组的患者 CAR 值明显高于 T2 组和 T1 组。在校正混杂因素后，T3 组在逻辑回归模型中使用 CAR 值的住院死亡率是 T1 组（参考组）的 8.2 倍（95%CI：4.2-48.1）。
结论
据我们所知，这是第一项证明 CAR 对 COVID-19 患者住院死亡率具有预测价值的研究。
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