and Gene Mutations in Acute Myeloid Leukemia.

A number of mutations have been reported to occur in patients with acute myeloid leukemia (AML), of which and genes mutations are the commonest and have important diagnostic and therapeutic implications. Molecular testing for and genes was performed in 92 de-novo AML patients. The frequency and characteristics of and mutations were analyzed. and mutations were seen in 22.8% and 16.3% of patients, respectively. Amongst mutations, -ITD mutation was seen in 8.7% cases, -TKD in 5.4%, and -ITD+TKD in 2.2% cases. Certain associations between the gene mutations and clinical characteristics were found, including in mutated group- female preponderance, higher incidence in M4/M5 categories and decreased expression of CD34 and HLA-DR; and in -ITD mutated group- higher age of presentation, higher total leucocyte count and blast percentage. - AML patients with and mutations have differences in clinical and hematological features, which might represent their different molecular mechanism in leukemogenesis. The frequency of and mutations in this study was comparable to reports from Asian countries but lower than that reported from western countries. However, as the number of patients in the study was less, a larger number of patients need to be studied to corroborate these findings.