协调逃避和空间导航回路协调灵活的飞行以避开威胁。
Coordination of escape and spatial navigation circuits orchestrates versatile flight from threats.
机构信息
Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Department of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
出版信息
Neuron. 2021 Jun 2;109(11):1848-1860.e8. doi: 10.1016/j.neuron.2021.03.033. Epub 2021 Apr 15.
Naturalistic escape requires versatile context-specific flight with rapid evaluation of local geometry to identify and use efficient escape routes. It is unknown how spatial navigation and escape circuits are recruited to produce context-specific flight. Using mice, we show that activity in cholecystokinin-expressing hypothalamic dorsal premammillary nucleus (PMd-cck) cells is sufficient and necessary for context-specific escape that adapts to each environment's layout. In contrast, numerous other nuclei implicated in flight only induced stereotyped panic-related escape. We reasoned the dorsal premammillary nucleus (PMd) can induce context-specific escape because it projects to escape and spatial navigation nuclei. Indeed, activity in PMd-cck projections to thalamic spatial navigation circuits is necessary for context-specific escape induced by moderate threats but not panic-related stereotyped escape caused by perceived asphyxiation. Conversely, the PMd projection to the escape-inducing dorsal periaqueductal gray projection is necessary for all tested escapes. Thus, PMd-cck cells control versatile flight, engaging spatial navigation and escape circuits.
自然逃避需要多功能的上下文特定飞行，快速评估局部几何形状以识别和使用有效的逃避路线。目前尚不清楚空间导航和逃避电路如何被招募来产生上下文特定的飞行。使用小鼠，我们表明，表达胆囊收缩素的下丘脑背前乳突核（PMd-cck）细胞的活动足以且对于适应每个环境布局的上下文特定的逃逸是必要的。相比之下，许多其他与飞行有关的核仅引起刻板的与恐慌相关的逃逸。我们推断背前乳突核（PMd）可以诱导上下文特定的逃逸，因为它投射到逃逸和空间导航核。事实上，PMd-cck 投射到丘脑空间导航回路的活动对于由中度威胁引起的上下文特定的逃逸是必要的，但对于由感知窒息引起的刻板的与恐慌相关的逃逸则不是。相反，PMd 投射到诱导逃逸的背侧导水管周围灰质的投射对于所有测试的逃逸都是必要的。因此，PMd-cck 细胞控制着多功能的飞行，涉及空间导航和逃逸回路。
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