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生物打印技术在工程心脏组织中的最新进展。

Recent advances in bioprinting technologies for engineering cardiac tissue.

机构信息

Department of Biotechnology, Indian Institute of Technology Kharagpur, West Bengal 721302, India.

Research Center "E. Piaggio" and Department of Information Engineering, University of Pisa, Largo Lucio Lazzarino 1, 56122 Pisa, Italy.

出版信息

Mater Sci Eng C Mater Biol Appl. 2021 May;124:112057. doi: 10.1016/j.msec.2021.112057. Epub 2021 Mar 25.

Abstract

Annually increasing incidence of cardiac-related disorders and cardiac tissue's minimal regenerative capacity have motivated the researchers to explore effective therapeutic strategies. In the recent years, bioprinting technologies have witnessed a great wave of enthusiasm and have undergone steady advancements over a short period, opening the possibilities for recreating engineered functional cardiac tissue models for regenerative and diagnostic applications. With this perspective, the current review delineates recent developments in the sphere of engineered cardiac tissue fabrication, using traditional and advanced bioprinting strategies. The review also highlights different printing ink formulations, available cellular opportunities, and aspects of personalized medicines in the context of cardiac tissue engineering and bioprinting. On a concluding note, current challenges and prospects for further advancements are also discussed.

摘要

逐年增加的心脏相关疾病发病率和心脏组织的极小再生能力促使研究人员探索有效的治疗策略。近年来,生物打印技术引起了极大的热情,在短时间内经历了稳步的发展,为再生和诊断应用创造了构建工程化功能性心脏组织模型的可能性。有鉴于此,本综述描述了使用传统和先进的生物打印策略构建工程化心脏组织方面的最新进展。该综述还强调了不同的打印墨水配方、可用的细胞机会以及个性化药物在心脏组织工程和生物打印方面的应用。最后,还讨论了当前的挑战和进一步发展的前景。

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