干扰素诱导的 GTPases 协调宿主细胞自主防御细菌病原体。
Interferon-induced GTPases orchestrate host cell-autonomous defence against bacterial pathogens.
机构信息
Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
出版信息
Biochem Soc Trans. 2021 Jun 30;49(3):1287-1297. doi: 10.1042/BST20200900.
Interferon (IFN)-induced guanosine triphosphate hydrolysing enzymes (GTPases) have been identified as cornerstones of IFN-mediated cell-autonomous defence. Upon IFN stimulation, these GTPases are highly expressed in various host cells, where they orchestrate anti-microbial activities against a diverse range of pathogens such as bacteria, protozoan and viruses. IFN-induced GTPases have been shown to interact with various host pathways and proteins mediating pathogen control via inflammasome activation, destabilising pathogen compartments and membranes, orchestrating destruction via autophagy and the production of reactive oxygen species as well as inhibiting pathogen mobility. In this mini-review, we provide an update on how the IFN-induced GTPases target pathogens and mediate host defence, emphasising findings on protection against bacterial pathogens.
干扰素（IFN）诱导的鸟苷三磷酸水解酶（GTPases）已被确定为 IFN 介导的细胞自主防御的基石。在 IFN 刺激后，这些 GTPases 在各种宿主细胞中高度表达，在那里它们协调针对多种病原体（如细菌、原生动物和病毒）的抗微生物活性。已经表明，IFN 诱导的 GTPases 与各种宿主途径和蛋白相互作用，通过炎症小体激活来介导病原体控制，破坏病原体区室和膜的稳定性，通过自噬进行协调破坏以及产生活性氧，以及抑制病原体的迁移。在这篇迷你综述中，我们提供了关于 IFN 诱导的 GTPases 如何靶向病原体和介导宿主防御的最新信息，强调了针对细菌病原体的保护作用的发现。
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