TMEM41B 和 VMP1 是磷脂翻转酶。
TMEM41B and VMP1 are phospholipid scramblases.
机构信息
Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), State Key Laboratory of Biotherapy, West China Hospital, College of Life Sciences, Sichuan University, Chengdu, Sichuan, China.
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.
出版信息
Autophagy. 2021 Aug;17(8):2048-2050. doi: 10.1080/15548627.2021.1937898. Epub 2021 Jun 12.
TMEM41B and VMP1, two endoplasmic reticulum (ER)-resident transmembrane proteins, play important roles in regulating the formation of lipid droplets (LDs), autophagy initiation, and viral infection. However, the biochemical functions of TMEM41B and VMP1 are unclear. A lipids distribution screen suggested TMEM41B and VMP1 are critical to the normal distribution of cholesterol and phosphatidylserine. Biochemical analyses unveiled that TMEM41B and VMP1 have scramblase activity. These findings shed light on the mechanism by which TMEM41B and VMP1 regulate LD formation, lipids distribution, macroautophagy, and viral infection.
TMEM41B 和 VMP1 是两种内质网（ER）驻留的跨膜蛋白，在调节脂滴（LD）形成、自噬起始和病毒感染方面发挥着重要作用。然而，TMEM41B 和 VMP1 的生化功能尚不清楚。脂质分布筛选表明 TMEM41B 和 VMP1 对胆固醇和磷脂酰丝氨酸的正常分布至关重要。生化分析揭示了 TMEM41B 和 VMP1 具有翻转酶活性。这些发现揭示了 TMEM41B 和 VMP1 调节 LD 形成、脂质分布、巨自噬和病毒感染的机制。
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