Chan Daniel Zl, Stewart Ralph Ah, Kerr Andrew J, Dicker Bridget, Kyle Campbell V, Adamson Philip D, Devlin Gerry, Edmond John, El-Jack Seif, Elliott John M, Fisher Nick, Flynn Charmaine, Lee Mildred, Liao Yi-Wen Becky, Rhodes Maxine, Scott Tony, Smith Tony, Stiles Martin K, Swain Andrew H, Todd Verity F, Webster Mark Wi, Williams Michael Ja, White Harvey D, Somaratne Jithendra B
Greenlane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand.
Department of Cardiology, Middlemore Hospital, Private Bag 93311, Otahuhu, Auckland 1640, New Zealand.
Lancet Reg Health West Pac. 2020 Dec;5:100056. doi: 10.1016/j.lanwpc.2020.100056. Epub 2020 Nov 20.
Countries with a high incidence of coronavirus 2019 (COVID-19) reported reduced hospitalisations for acute coronary syndromes (ACS) during the pandemic. This study describes the impact of a nationwide lockdown on ACS hospitalisations in New Zealand (NZ), a country with a low incidence of COVID-19.
All patients admitted to a NZ Hospital with ACS who underwent coronary angiography in the All NZ ACS Quality Improvement registry during the lockdown (23 March - 26 April 2020) were compared with equivalent weeks in 2015-2019. Ambulance attendances and regional community troponin-I testing were compared for lockdown and non-lockdown (1 July 2019 to 16 February 2020) periods.
Hospitalisation for ACS was lower during the 5-week lockdown (105 vs. 146 per-week, rate ratio 0•72 [95% CI 0•61-0•83], = 0.003). This was explained by fewer admissions for non-ST-segment elevation ACS (NSTE-ACS; = 0•002) but not ST-segment elevation myocardial infarction (STEMI; = 0•31). Patient characteristics and in-hospital mortality were similar. For STEMI, door-to-balloon times were similar (70 vs. 72 min, = 0•52). For NSTE-ACS, there was an increase in percutaneous revascularisation (59% vs. 49%, <0•001) and reduction in surgical revascularisation (9% vs. 15%, = 0•005). There were fewer ambulance attendances for cardiac arrests (98 vs. 110 per-week, = 0•04) but no difference for suspected ACS (408 vs. 420 per-week, = 0•44). Community troponin testing was lower throughout the lockdown (182 vs. 394 per-week, <0•001).
Despite the low incidence of COVID-19, there was a nationwide decrease in ACS hospitalisations during the lockdown. These findings have important implications for future pandemic planning.
The ANZACS-QI registry receives funding from the New Zealand Ministry of Health.
2019冠状病毒病(COVID-19)高发病率国家报告称,疫情期间急性冠脉综合征(ACS)住院人数减少。本研究描述了在COVID-19低发病率国家新西兰(NZ),全国范围封锁对ACS住院情况的影响。
将在封锁期间(2020年3月23日至4月26日)在全新西兰ACS质量改进登记处接受冠状动脉造影的所有入住新西兰医院的ACS患者与2015 - 2019年同期周数据进行比较。比较封锁期间和非封锁期间(2019年7月1日至2020年2月16日)的救护车出诊情况及区域社区肌钙蛋白I检测情况。
在为期5周的封锁期间,ACS住院人数较低(每周105例对146例,率比0.72 [95% CI 0.61 - 0.83],P = 0.003)。这是由于非ST段抬高型ACS(NSTE-ACS)入院人数减少(P = 0.002),而ST段抬高型心肌梗死(STEMI)入院人数未减少(P = 0.31)。患者特征和院内死亡率相似。对于STEMI,门球时间相似(70分钟对72分钟,P = 0.52)。对于NSTE-ACS,经皮血管重建术有所增加(59%对49%,P < 0.001),外科血管重建术有所减少(9%对15%,P = 0.005)。心脏骤停的救护车出诊次数减少(每周98次对110次,P = 0.04),但疑似ACS的出诊次数无差异(每周408次对420次,P = 0.44)。在整个封锁期间,社区肌钙蛋白检测次数较低(每周182次对394次,P < 0.001)。
尽管COVID-19发病率较低,但在封锁期间全国范围内ACS住院人数有所下降。这些发现对未来的疫情规划具有重要意义。
澳新ACS质量改进登记处接受新西兰卫生部的资助。