Tu Yinfang, Bao Yuqian, Zhang Pin
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai 200233, China.
Department of Endocrinology and Metabolism, Jinshan District Central Hospital of Shanghai Sixth People's Hospital, Shanghai 201599, China.
J Mol Cell Biol. 2021 Jul 7;13(8):594-609. doi: 10.1093/jmcb/mjab039.
Obesity and its related complications comprise a serious public health problem worldwide, and obesity is increasing in China. Metabolic surgery is a new type of treatment with unique advantages in weight loss and obesity-related metabolic complications. The pathogenesis of obesity is complex and not yet fully understood. Here, we review the current efficacy and safety of metabolic surgery, as well as recent progress in mechanistic studies and surgical procedures in China. The exciting and rapid advances in this field provide new opportunities for patients with obesity and strike a balance between long-term effectiveness and safety.
肥胖及其相关并发症是全球范围内严重的公共卫生问题,且在中国肥胖问题日益严重。代谢手术是一种新型治疗方法,在减重及肥胖相关代谢并发症方面具有独特优势。肥胖的发病机制复杂,尚未完全明确。在此,我们综述了中国代谢手术的当前疗效和安全性,以及机制研究和手术操作方面的最新进展。该领域令人振奋的快速发展为肥胖患者提供了新机遇,并在长期有效性和安全性之间取得了平衡。