阿尔茨海默病小鼠模型中的胆碱能神经变性

Cholinergic neurodegeneration in Alzheimer disease mouse models.

作者信息

Shekari Arman, Fahnestock Margaret

机构信息

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.

出版信息

Handb Clin Neurol. 2021;182:191-209. doi: 10.1016/B978-0-12-819973-2.00013-7.

DOI:10.1016/B978-0-12-819973-2.00013-7

PMID:34266592

Abstract

Cholinergic signaling is critical for cognitive function. The basal forebrain is the major cholinergic output of the central nervous system. Degeneration of basal forebrain cholinergic neurons is a hallmark of Alzheimer's disease (AD). Mouse models are invaluable tools in disease research and have been used to study AD for over 25 years. However, animal models of AD vary greatly with respect to the degree of cholinergic degeneration observed. The following review will outline the most influential animal models of AD with an emphasis on the basal forebrain cholinergic system.

摘要

胆碱能信号传导对认知功能至关重要。基底前脑是中枢神经系统主要的胆碱能输出部位。基底前脑胆碱能神经元的退化是阿尔茨海默病（AD）的一个标志。小鼠模型是疾病研究中非常有价值的工具，并且已经被用于研究AD超过25年了。然而，AD的动物模型在观察到的胆碱能退化程度方面差异很大。以下综述将概述最具影响力的AD动物模型，重点是基底前脑胆碱能系统。