IFITM 假基因编码的长非编码 RNA 的间接抗病毒潜力。
The Indirect Antiviral Potential of Long Noncoding RNAs Encoded by IFITM Pseudogenes.
机构信息
HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.
出版信息
J Virol. 2021 Oct 13;95(21):e0068021. doi: 10.1128/JVI.00680-21. Epub 2021 Jul 28.
Abstract
The interferon-induced transmembrane () gene family performs multiple functions in immunity, including inhibition of virus entry into cells. The repertoire varies widely between species and consists of protein-coding genes and pseudogenes. The selective forces driving pseudogenization within gene families are rarely understood. In this issue, the human pseudogene is characterized as a virus-induced, long noncoding RNA that contributes to restriction of influenza A virus by regulating mRNA levels of , , and .
摘要
干扰素诱导跨膜（）基因家族在免疫中发挥多种功能，包括抑制病毒进入细胞。该基因家族在物种间的多样性很大，由蛋白编码基因和假基因组成。驱动基因家族中假基因化的选择压力很少被理解。在本期中，人类假基因被描述为一种病毒诱导的长非编码 RNA，通过调节、和的 mRNA 水平来限制甲型流感病毒。
相似文献
1
The Indirect Antiviral Potential of Long Noncoding RNAs Encoded by IFITM Pseudogenes.
J Virol. 2021 Oct 13;95(21):e0068021. doi: 10.1128/JVI.00680-21. Epub 2021 Jul 28.
2
Long Noncoding RNA IFITM4P Regulates Host Antiviral Responses by Acting as a Competing Endogenous RNA.
J Virol. 2021 Oct 13;95(21):e0027721. doi: 10.1128/JVI.00277-21. Epub 2021 Jul 21.
3
IFITM Proteins That Restrict the Early Stages of Respiratory Virus Infection Do Not Influence Late-Stage Replication.
J Virol. 2021 Sep 27;95(20):e0083721. doi: 10.1128/JVI.00837-21. Epub 2021 Jul 28.
4
pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs.
J Virol. 2017 May 12;91(11). doi: 10.1128/JVI.00246-17. Print 2017 Jun 1.
5
Duck Interferon-Inducible Transmembrane Protein 3 Mediates Restriction of Influenza Viruses.
J Virol. 2015 Oct 14;90(1):103-16. doi: 10.1128/JVI.01593-15. Print 2016 Jan 1.
6
Influenza A Virus Facilitates Its Infectivity by Activating p53 to Inhibit the Expression of Interferon-Induced Transmembrane Proteins.
Front Immunol. 2018 May 31;9:1193. doi: 10.3389/fimmu.2018.01193. eCollection 2018.
7
Identification of Residues Controlling Restriction versus Enhancing Activities of IFITM Proteins on Entry of Human Coronaviruses.
J Virol. 2018 Feb 26;92(6). doi: 10.1128/JVI.01535-17. Print 2018 Mar 15.
8
Interferon-Induced Transmembrane Proteins Inhibit Infection by the Kaposi's Sarcoma-Associated Herpesvirus and the Related Rhesus Monkey Rhadinovirus in a Cell-Specific Manner.
mBio. 2021 Dec 21;12(6):e0211321. doi: 10.1128/mBio.02113-21.
9
The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry.
J Biol Chem. 2015 Oct 23;290(43):25946-59. doi: 10.1074/jbc.M115.657346. Epub 2015 Sep 9.
10
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.
Cell. 2009 Dec 24;139(7):1243-54. doi: 10.1016/j.cell.2009.12.017.
引用本文的文献
1
Evolution of primate interferon-induced transmembrane proteins (IFITMs): a story of gain and loss with a differentiation into a canonical cluster and IFITM retrogenes.
Front Microbiol. 2023 Jul 26;14:1213685. doi: 10.3389/fmicb.2023.1213685. eCollection 2023.
2
Restriction of SARS-CoV-2 replication by receptor transporter protein 4 (RTP4).
mBio. 2023 Aug 31;14(4):e0109023. doi: 10.1128/mbio.01090-23. Epub 2023 Jun 29.
3
Downregulation of the Long Noncoding RNA IALNCR Targeting MAPK8/JNK1 Promotes Apoptosis and Antagonizes Bovine Viral Diarrhea Virus Replication in Host Cells.
J Virol. 2022 Sep 14;96(17):e0111322. doi: 10.1128/jvi.01113-22. Epub 2022 Aug 22.
4
LncRNA IFITM4P promotes immune escape by up-regulating PD-L1 via dual mechanism in oral carcinogenesis.
Mol Ther. 2022 Apr 6;30(4):1564-1577. doi: 10.1016/j.ymthe.2022.01.003. Epub 2022 Jan 17.
本文引用的文献
1
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.
Nat Commun. 2022 Feb 23;13(1):1018. doi: 10.1038/s41467-022-28508-0.
2
Long Noncoding RNA IFITM4P Regulates Host Antiviral Responses by Acting as a Competing Endogenous RNA.
J Virol. 2021 Oct 13;95(21):e0027721. doi: 10.1128/JVI.00277-21. Epub 2021 Jul 21.
3
Interferon-Induced Transmembrane Protein 3 Blocks Fusion of Diverse Enveloped Viruses by Altering Mechanical Properties of Cell Membranes.
ACS Nano. 2021 May 25;15(5):8155-8170. doi: 10.1021/acsnano.0c10567. Epub 2021 Mar 3.
4
miR-24 Targets the Transmembrane Glycoprotein Neuropilin-1 in Human Brain Microvascular Endothelial Cells.
Noncoding RNA. 2021 Feb 2;7(1):9. doi: 10.3390/ncrna7010009.
5
CD225 Proteins: A Family Portrait of Fusion Regulators.
Trends Genet. 2021 May;37(5):406-410. doi: 10.1016/j.tig.2021.01.004. Epub 2021 Jan 29.
6
Malignancy and IFITM3: Friend or Foe?
Front Oncol. 2020 Dec 8;10:593245. doi: 10.3389/fonc.2020.593245. eCollection 2020.
7
Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric state.
Elife. 2020 Oct 28;9:e58537. doi: 10.7554/eLife.58537.
8
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.
Science. 2020 Nov 13;370(6518):856-860. doi: 10.1126/science.abd2985. Epub 2020 Oct 20.
9
miR-24-3p promotes colon cancer progression by targeting ING1.
Signal Transduct Target Ther. 2020 Aug 25;5(1):171. doi: 10.1038/s41392-020-0206-y.
10
Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes.
Blood. 2019 Oct 17;134(16):1298-1311. doi: 10.1182/blood.2019000040.
Zotero 插件