Tirla Adrian, Vesa Cosmin Mihai, Cavalu Simona
Faculty of Medicine and Pharmacy, University of Oradea, 1 December Sq, 10, 410087 Oradea, Romania.
Diagnostics (Basel). 2021 Jul 21;11(8):1313. doi: 10.3390/diagnostics11081313.
Androgenic-Anabolic Steroids (AAS) abuse is known to play an important role in causing the systemic inflammatory response and multiple-organ dysfunction in healthy individuals. Although many of the undesirable effects of steroid abuse have been reported, at present, little is known about the effect of anabolic supplements and the correlation between cardiac and metabolic pathology. This paper presents a case of a 25 year old patient with a complex medical history after 6 months of steroid administration. Myocardial infraction, dyslipidemia, obesity, hyperuricemia, secondary diabetes, and chronic renal disease were identified after clinical and para-clinical examinations. The particularities of this case were interpreted in the context of a literature review, highlighting the effect of multi-organ damage as a result of the uncontrolled use of anabolic steroid supplements.
已知滥用雄激素-合成代谢类固醇(AAS)在导致健康个体出现全身炎症反应和多器官功能障碍方面起重要作用。尽管已报道了类固醇滥用的许多不良影响,但目前对于合成代谢补充剂的影响以及心脏和代谢病理学之间的相关性知之甚少。本文介绍了一名25岁患者在服用类固醇6个月后具有复杂病史的病例。经过临床和辅助检查,发现该患者患有心肌梗死、血脂异常、肥胖、高尿酸血症、继发性糖尿病和慢性肾病。结合文献综述对该病例的特殊性进行了解读,强调了滥用合成代谢类固醇补充剂导致多器官损害的影响。