中国北方人群中 MIR17HG 和 MIR155HG 基因变异与激素性股骨头坏死的关联。
Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China.
机构信息
Inner Mongolia Medical University, Hohhot, 010110, Jinshan Development Zone, China.
The Second Affiliated Hospital of Inner Mongolia Medical University, No. 1, Yingfang Road, Huhhot, 010030, Hui District, China.
出版信息
J Orthop Surg Res. 2021 Nov 15;16(1):673. doi: 10.1186/s13018-021-02669-y.
INTRODUCTION
Steroid-induced osteonecrosis of the femoral head (ONFH) is a disease of the bone. Metabolism and genetic factors are generally considered to play an important role. The purpose of this study was to investigate the relationship between single-nucleotide polymorphisms (SNPs) in MIR17HG and MIR155HG and the risk of steroid-induced ONFH in the population of northern China.
METHODS
A total of 199 steroid-induced ONFH patients and 506 healthy controls were recruited for the study. Four SNPs of MIR17HG and seven SNPs of MIR155HG were genotyped by Sequenom MassARRAY. ORs and 95% CIs were used to evaluate the relationship between these SNPs and steroid-induced ONFH.
RESULTS
In the codominant model, patients with the MIR17HG SNPs (rs7318578) AA genotype had an increased risk of steroid-induced ONFH (OR = 1.79, p = 0.039); in the recessive model, patients with the MIR17HG SNP (rs7318578) AA genotype had an increased risk of steroid-induced ONFH (OR = 1.78, p = 0.032). Stratified analysis showed that a MIR17HG SNP (rs7318578) and the MIR155HG SNPs (rs77218221, rs11911469, rs34904192 and rs4143370) were closely related to different unornamented phenotypes of steroid-induced ONFH. Analysis of the clinical indicators revealed significant differences in high-density lipoprotein (HDL-C) levels between the ONFH group and the control group (p = 0.005). In the MIR17HG SNP (rs75267932), patients with different genotypes had different levels of triglyceride (TG). The MIR155HG SNPs (rs77699734, rs1893650, and rs34904192) showed differences in triglyceride (TG), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) levels in patients with different genotypes.
CONCLUSION
Our results confirm that MIR17HG and MIR155HG gene mutations are associated with steroid-induced ONFH susceptibility in the population of northern China, providing new evidence for the early detection and prevention of ONFH.
简介
激素诱导性股骨头坏死（ONFH）是一种骨骼疾病。代谢和遗传因素通常被认为起着重要作用。本研究的目的是探讨中国北方人群中 MIR17HG 和 MIR155HG 单核苷酸多态性（SNPs）与激素诱导性 ONFH 风险之间的关系。
方法
本研究共纳入 199 例激素诱导性 ONFH 患者和 506 例健康对照者。采用Sequenom MassARRAY 技术对 MIR17HG 的 4 个 SNPs 和 MIR155HG 的 7 个 SNPs 进行基因分型。采用 OR 值和 95%CI 评估这些 SNPs 与激素诱导性 ONFH 之间的关系。
结果
在共显性模型中，MIR17HG 基因（rs7318578）AA 基因型的患者发生激素诱导性 ONFH 的风险增加（OR=1.79，p=0.039）；在隐性模型中，MIR17HG 基因（rs7318578）AA 基因型的患者发生激素诱导性 ONFH 的风险增加（OR=1.78，p=0.032）。分层分析表明，MIR17HG 基因（rs7318578）SNP 与 MIR155HG 基因（rs77218221、rs11911469、rs34904192 和 rs4143370）SNP 与激素诱导性 ONFH 的不同非修饰表型密切相关。临床指标分析显示，ONFH 组与对照组高密度脂蛋白（HDL-C）水平差异有统计学意义（p=0.005）。在 MIR17HG 基因（rs75267932）中，不同基因型患者的甘油三酯（TG）水平不同。MIR155HG 基因（rs77699734、rs1893650 和 rs34904192）的不同基因型患者的甘油三酯（TG）、高密度脂蛋白（HDL-C）和低密度脂蛋白（LDL-C）水平存在差异。
结论
本研究结果证实，MIR17HG 和 MIR155HG 基因突变与中国北方人群激素诱导性 ONFH 易感性相关，为 ONFH 的早期检测和预防提供了新的证据。
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