MIR17HG基因变异及MIR17HG启动子与中国汉族人群癌症易感性的关联：一项系统评价和荟萃分析

Association of genetic variants in MIR17HG and in the promoter of MIR17HG with susceptibility to cancer in Chinese Han population: a systematic review and meta-analysis.

作者信息

Tong Binghua, Zhang Zhaonan, Xu Zhaowei, Yang Yangyang

机构信息

School of Pharmacy, Binzhou Medical University, Yantai, 264003, China.

Yantai Affiliated Hospital of Binzhou Medical University, Yantai, 256603, China.

出版信息

BMC Cancer. 2025 Apr 7;25(1):631. doi: 10.1186/s12885-025-14018-x.

DOI:10.1186/s12885-025-14018-x

PMID:40197290

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11977879/

Abstract

BACKGROUND

The association between microRNA 17-92 cluster host gene (MIR17HG) polymorphisms and the risk of cancer has been evaluated in studies, here, we attempted to elucidate the relationship between 6 single nucleotide polymorphisms (SNPs) of MIR17HG (rs17735387 G > A, rs7336610 C > T, rs1428 C > A, rs7318578 A > C, rs72640334 C > A, and rs75267932 A > G), 3 SNPs in the promoter of MIR17HG (rs9588884 C > G, rs982873 T > C, and rs1813389 A > G) and susceptibility to cancer in Chinese Han population.

METHODS

Systematic literature research from databases were performed with strict eligibility criteria to include the relevant studies for this meta-analysis. Association between the SNPs of MIR17HG and cancer risk was estimated by pooling the odds ratios (ORs) with 95% confidence interval (95% CI) in five genetic models (allelic model, dominant model, recessive model, homozygous model, and heterozygous model).

RESULTS

The pooled meta-analysis showed that there was no significant association between rs17735387 G > A, rs7336610 C > T, rs1428 C > A, rs7318578 A > C, rs72640334 C > A, and rs75267932 A > G and cancer risk in Chinese Han population. However, for the SNPs in the promoter of MIR17HG, rs9588884 C > G and rs982873 T > C could decrease cancer risk in most genetic models, but not rs1813389 A > G.

CONCLUSION

This present meta-analysis identified 2 SNPs in the promoter of MIR17HG (rs9588884 C > G and rs982873 T > C) may be protective factors against cancer in Chinese Han population.

摘要

背景

已有研究评估了微小RNA 17-92簇宿主基因（MIR17HG）多态性与癌症风险之间的关联，在此，我们试图阐明MIR17HG的6个单核苷酸多态性（SNP）（rs17735387 G＞A、rs7336610 C＞T、rs1428 C＞A、rs7318578 A＞C、rs72640334 C＞A和rs75267932 A＞G）、MIR17HG启动子中的3个SNP（rs9588884 C＞G、rs982873 T＞C和rs1813389 A＞G）与中国汉族人群癌症易感性之间的关系。

方法

根据严格的纳入标准对数据库进行系统文献检索，以纳入本荟萃分析的相关研究。通过汇总五个遗传模型（等位基因模型、显性模型、隐性模型、纯合子模型和杂合子模型）中的优势比（OR）及95%置信区间（95%CI）来评估MIR17HG的SNP与癌症风险之间的关联。

结果

汇总的荟萃分析表明，rs17735387 G＞A、rs7336610 C＞T、rs1428 C＞A、rs7318578 A＞C、rs72640334 C＞A和rs75267932 A＞G与中国汉族人群的癌症风险之间无显著关联。然而，对于MIR17HG启动子中的SNP，rs9588884 C＞G和rs982873 T＞C在大多数遗传模型中可降低癌症风险，但rs1813389 A＞G则不然。