Suppr超能文献

昆虫基因组中的 RNA 病毒外显子。

RNA virus EVEs in insect genomes.

机构信息

Departamento de Entomologia e Núcleo de Bioinformática, Instituto Aggeu Magalhães (IAM), Fundação Oswaldo Cruz (FIOCRUZ), Recife, Pernambuco, CEP: 50.740-465, Brazil.

出版信息

Curr Opin Insect Sci. 2022 Feb;49:42-47. doi: 10.1016/j.cois.2021.11.005. Epub 2021 Nov 26.

Abstract

Insects are infected by a diverse set of RNA viruses that are more broadly distinguished by their ability to infect single or multiple host species. During replication into the host cell, partial or complete double strand DNA derived from the viral genome may be integrated into their host genomes giving origin to endogenous viral elements (EVEs). EVEs from RNA viruses have been identified in a variety of insect genomes showing different evolutionary trajectories: from highly degraded viral genomic remains to partial and complete viral coding regions. Limited functional knowledge exists about RNA EVEs impact on hosts and circulating viruses, but exciting results are emerging showing a complex arms race interplay that influences the evolutionary trajectory of these interacting entities.

摘要

昆虫受到多种 RNA 病毒的感染,这些病毒更广泛地根据其感染单一或多种宿主物种的能力来区分。在进入宿主细胞的复制过程中,部分或完整的双链 DNA 可能来源于病毒基因组并整合到宿主基因组中,从而产生内源性病毒元件(EVEs)。在各种昆虫基因组中已经鉴定出 RNA 病毒的 EVEs,它们表现出不同的进化轨迹:从高度降解的病毒基因组残留物到部分和完整的病毒编码区。关于 RNA EVEs 对宿主和循环病毒的影响,我们的功能知识有限,但令人兴奋的结果正在出现,表明这一复杂的军备竞赛相互作用影响了这些相互作用实体的进化轨迹。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验