用于兽医学应用的树枝状大分子纳米平台：简要概述。
Dendrimer nanoplatforms for veterinary medicine applications: A concise overview.
作者信息
Mignani Serge, Shi Xiangyang, Rodrigues João, Tomás Helena, Majoral Jean-Pierre
机构信息
Université Paris Descartes, PRES Sorbonne Paris Cité, CNRS UMR 860, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique, 45, Rue des Saints Peres, 75006 Paris, France; CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal.
CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal; College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China.
出版信息
Drug Discov Today. 2022 May;27(5):1251-1260. doi: 10.1016/j.drudis.2022.01.001. Epub 2022 Jan 6.
Within the nanoparticle (NP) space, dendrimers are becoming increasingly important in the field of nanomedicine, not only to treat human diseases, but also in veterinary medicine, which represents a new therapeutic approach. Major applications include using dendrimers to tackle highly contagious foot-and-mouth disease virus (FMDV) and swine fever virus (SFV) in pigs, FMDV in cattle, hypothermic circulatory arrest (HCA) in dogs, rabies, and H9N2 avian influenza virus in chickens. As we review here, intramuscular (im) subcutaneous (sc), intravenous (iv), and intraperitoneal (ip) routes of administration can be used for the successful application of dendrimers in animals.
在纳米颗粒（NP）领域，树枝状大分子在纳米医学领域正变得越来越重要，不仅用于治疗人类疾病，也用于兽医学，这代表了一种新的治疗方法。主要应用包括使用树枝状大分子来应对猪的高度传染性口蹄疫病毒（FMDV）和猪瘟病毒（SFV）、牛的FMDV、犬的低温循环停止（HCA）、狂犬病以及鸡的H9N2禽流感病毒。正如我们在此所综述的，肌肉内（im）、皮下（sc）、静脉内（iv）和腹膜内（ip）给药途径可用于树枝状大分子在动物体内的成功应用。
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