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兽医学中的纳米载体:改善骨肉瘤传统治疗方法面临的一项挑战。

Nanocarriers in Veterinary Medicine: A Challenge for Improving Osteosarcoma Conventional Treatments.

作者信息

Sapino Simona, Chindamo Giulia, Chirio Daniela, Morel Silvia, Peira Elena, Vercelli Cristina, Gallarate Marina

机构信息

Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, 10125 Torino, Italy.

Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale A. Avogadro, 28100 Novara, Italy.

出版信息

Nanomaterials (Basel). 2022 Dec 19;12(24):4501. doi: 10.3390/nano12244501.

Abstract

In recent years, several nanocarrier-based drug delivery systems, such as polymeric nanoparticles, solid lipid nanoparticles, metallic nanoparticles, liposomes, and others, have been explored to target and treat a wide variety of diseases. Their employment has brought many benefits, not only to human medicine but also to veterinary medicine, albeit at a slower rate. Soon, the use of nanocarriers could revolutionize the animal health sector, and many veterinary therapies will be more effective as a result. The purpose of this review is to offer an overview of the main applications of nanocarriers in the veterinary field, from supplements for animal health and reproduction to nanovaccines and nanotherapies. Among the major pathologies that can affect animals, special attention is given to canine osteosarcoma (OSA): a comparison with human OSA is provided and the main treatment options are reviewed emphasizing the benefits that nanocarriers could bring in the treatment of this widespread disease.

摘要

近年来,人们探索了几种基于纳米载体的药物递送系统,如聚合物纳米颗粒、固体脂质纳米颗粒、金属纳米颗粒、脂质体等,用于靶向治疗多种疾病。它们的应用不仅给人类医学带来了诸多益处,也给兽医学带来了好处,尽管速度较慢。很快,纳米载体的使用可能会给动物健康领域带来变革,许多兽医治疗方法也将因此变得更加有效。本综述的目的是概述纳米载体在兽医领域的主要应用,从动物健康和繁殖补充剂到纳米疫苗和纳米疗法。在可能影响动物的主要疾病中,特别关注犬骨肉瘤(OSA):将其与人类OSA进行比较,并综述主要治疗选择,强调纳米载体在治疗这种广泛疾病中可能带来的益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c2c/9785518/8400d9f99089/nanomaterials-12-04501-g001.jpg

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