Zhang Chenchen, Li Lixiang, Jin Biying, Xu Xinyan, Zuo Xiuli, Li Yanqing, Li Zhen
Department of Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Laboratory of Translational Gastroenterology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Front Microbiol. 2021 Dec 23;12:724449. doi: 10.3389/fmicb.2021.724449. eCollection 2021.
The delivery mode is an important factor driving alteration in the gut microbiota during the neonatal period. Several studies prove that the alteration of gut microbiota induced by cesarean section could influence the activation of intestinal epithelial cells and the development of immune system. Further, some autoimmune and metabolic disorders may be related to the microbiota dysbiosis in infants caused by cesarean section. It is noteworthy that probiotics could promote the intestinal microecology, which may further prevent and treat cesarean section related diseases. This review summarized the great significance of delivery mode on microbiota and health, as well as provided clinically feasible methods for the prevention and treatment of cesarean section related gut diseases.
分娩方式是新生儿期驱动肠道微生物群改变的一个重要因素。多项研究证明,剖宫产引起的肠道微生物群改变会影响肠道上皮细胞的激活和免疫系统的发育。此外,一些自身免疫性和代谢性疾病可能与剖宫产导致的婴儿微生物群失调有关。值得注意的是,益生菌可以促进肠道微生态,这可能进一步预防和治疗与剖宫产相关的疾病。本综述总结了分娩方式对微生物群和健康的重大意义,并提供了预防和治疗与剖宫产相关肠道疾病的临床可行方法。