口腔鳞状细胞癌的关键途径：分子生物标志物和治疗干预。
Critical pathways of oral squamous cell carcinoma: molecular biomarker and therapeutic intervention.
机构信息
Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Department of Radiation Oncology, Washington University in Saint Louis, St. Louis, USA.
出版信息
Med Oncol. 2022 Jan 20;39(3):30. doi: 10.1007/s12032-021-01633-4.
The rapid growth of oral cancer is a significant concern, especially in developing countries due to the advanced lifestyle and 5-year survival despite advanced multimodality of cancer care. The poor modality might be due to the detection of disease in the advanced stage. Early detection and development of novel therapies can improve oral cancer patient survival. The PI3K/AKT/mTOR and RAS-RAF-MEK-ERK are very extensively exploited pathways in oral cancer. These pathways are very critical in the progression of tumorigenesis in oral cancer. This review focuses on the association of Ras/Raf/MEK/ERK and PI3K/AKT/mTOR pathways in terms of protein expression level, genetic mutation, and therapeutic intervention in oral cancer.
口腔癌的快速增长令人担忧，尤其是在发展中国家，由于生活方式的进步，癌症治疗的多模式也在进步，但 5 年生存率仍较低。治疗效果不佳可能是由于疾病在晚期才被发现。早期发现和开发新的治疗方法可以提高口腔癌患者的生存率。PI3K/AKT/mTOR 和 RAS-RAF-MEK-ERK 通路在口腔癌中被广泛研究。这些通路在口腔癌的肿瘤发生进展中非常关键。本综述重点关注 Ras/Raf/MEK/ERK 和 PI3K/AKT/mTOR 通路在口腔癌中的蛋白表达水平、基因突变和治疗干预方面的关联。
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