Physicochemical characteristics and antimicrobial activity of L. essential oil and carvacrol on cariogenic bacteria: an and study.

Natural antimicrobial products have been historically used for the prevention and control of biofilm-dependent oral diseases. We determined the physicochemical characteristics of L. essential oil (OEO) and carvacrol (CAR), and their antimicrobial activity against cariogenic bacteria. analysis was further carried out to examine the pharmacokinetics of CAR. The antimicrobial activity of OEO and CAR was determined through agar diffusion test, biofilm assays, and the checkboard test. Data were analyzed by Tukey's post hoc test. OEO showed inhibitory activity on bacterial growth, which was enhanced with the addition of CAR and greater than that of CAR alone. analysis indicated good theoretical bioavailability of CAR. CAR showed effective physicochemical characteristics as an antimicrobial drug due to its favorable theoretical absorption and distribution kinetics. Collectively, our findings suggest that OEO and CAR warrant further investigations as promising natural products for controlling cariogenic biofilms.