母亲 Tdap 推荐与幼儿百日咳住院的关联。
Association of Maternal Tdap Recommendations With Pertussis Hospitalizations of Young Infants.
机构信息
Division of Pediatric Hospital Medicine, University Hospitals Rainbow Babies and Children's Hospital, Cleveland, Ohio.
Division of General Pediatrics, Boston Children's Hospital, Boston, Massachusetts.
出版信息
Hosp Pediatr. 2022 Mar 1;12(3):e106-e109. doi: 10.1542/hpeds.2021-006323.
BACKGROUND
It is well established that young infants have the highest risk of severe pertussis, which often results in hospitalization. Since the 2012 recommendation of administering tetanus toxoid, diphtheria toxoid, and acellular pertussis (Tdap) vaccine for every pregnancy, evaluation of pertussis hospitalizations among young infants in the United States has been limited.
METHODS
In this ecological study, we used the Kids' Inpatient Database, the largest all-payer pediatric inpatient database in the United States, to study pertussis hospitalizations among infants <1 month of age from 2000 to 2016.
RESULTS
The overall rate of pertussis hospitalizations before the Tdap vaccination recommendation was 5.06 per 100 000 infants (95% confidence interval, 4.36-5.76) and 2.15 per 100 000 infants (95% confidence interval, 1.49-2.81) afterward.
CONCLUSIONS
This study supports maternal vaccination against pertussis as an important strategy in protecting young infants, and continued evaluation is needed to assess the long-term trends in hospitalization.
背景
众所周知，婴幼儿患严重百日咳的风险最高，且常需住院治疗。自 2012 年推荐孕妇接种破伤风类毒素、白喉类毒素和无细胞百日咳（Tdap）疫苗以来，美国对婴幼儿百日咳住院情况的评估一直受到限制。
方法
在这项生态学研究中，我们使用了美国最大的全付费儿科住院数据库——儿童住院数据库（Kids' Inpatient Database），研究了 2000 年至 2016 年期间 <1 个月大的婴儿的百日咳住院情况。
结果
在 Tdap 疫苗接种建议之前，百日咳住院率总体为每 10 万名婴儿 5.06 例（95%置信区间为 4.36-5.76），之后为每 10 万名婴儿 2.15 例（95%置信区间为 1.49-2.81）。
结论
本研究支持针对百日咳的母体疫苗接种是保护婴幼儿的重要策略，需要继续评估以评估住院治疗的长期趋势。
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