AMPK 与运动适应
AMPK and the Adaptation to Exercise.
机构信息
Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA; email:
Departments of Medicine, Pharmacology, and Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
出版信息
Annu Rev Physiol. 2022 Feb 10;84:209-227. doi: 10.1146/annurev-physiol-060721-095517.
Abstract
Noncommunicable diseases are chronic diseases that contribute to death worldwide, but these diseases can be prevented and mitigated with regular exercise. Exercise activates signaling molecules and the transcriptional network to promote physiological adaptations, such as fiber type transformation, angiogenesis, and mitochondrial biogenesis. AMP-activated protein kinase (AMPK) is a master regulator that senses the energy state, promotes metabolism for glucose and fatty acid utilization, and mediates beneficial cellular adaptations in many vital tissues and organs. This review focuses on the current, integrative understanding of the role of exercise-induced activation of AMPK in the regulation of system metabolism and promotion of health benefits.
摘要
非传染性疾病是导致全球死亡的慢性疾病，但这些疾病可以通过定期锻炼来预防和减轻。锻炼激活信号分子和转录网络，促进生理适应，如纤维类型转变、血管生成和线粒体生物发生。AMP 激活的蛋白激酶 (AMPK) 是一种感知能量状态的主调控因子，促进葡萄糖和脂肪酸利用的代谢，并介导许多重要组织和器官的有益细胞适应。本综述重点介绍了运动诱导的 AMPK 激活在调节系统代谢和促进健康益处方面的最新综合认识。
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