miR-221/222作为癌症及其他疾病治疗干预的生物标志物和靶点：一项系统综述
miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review.
作者信息
Di Martino Maria Teresa, Arbitrio Mariamena, Caracciolo Daniele, Cordua Alessia, Cuomo Onofrio, Grillone Katia, Riillo Caterina, Caridà Giulio, Scionti Francesca, Labanca Caterina, Romeo Caterina, Siciliano Maria Anna, D'Apolito Maria, Napoli Cristina, Montesano Martina, Farenza Valentina, Uppolo Valentina, Tafuni Michele, Falcone Federica, D'Aquino Giuseppe, Calandruccio Natale Daniele, Luciano Francesco, Pensabene Licia, Tagliaferri Pierosandro, Tassone Pierfrancesco
机构信息
Department of Experimental and Clinical Medicine, Magna Græcia University, Catanzaro, Italy.
Institute for Research and Biomedical Innovation (IRIB), Italian National Council (CNR), Catanzaro, Italy.
出版信息
Mol Ther Nucleic Acids. 2022 Feb 11;27:1191-1224. doi: 10.1016/j.omtn.2022.02.005. eCollection 2022 Mar 8.
Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports the potential of miR-221 silencing as promising therapeutic intervention. In this systematic review, we selected papers from the principal databases (PubMed, MedLine, Medscape, ASCO, ESMO) between January 2012 and December 2020, using the keywords "miR-221" and the specific keywords related to the most important hematologic and solid malignancies, and some non-malignant diseases, to define and characterize deregulated miR-221 as a valuable therapeutic target in the modern vision of molecular medicine. We found a major role of miR-221 in this view.
在人类恶性肿瘤中失调的微小RNA（miR）中，miR-221因其致癌作用以及作为一种有前景的生物标志物而受到广泛研究。此外，最近的证据表明miR-221是慢性肝损伤和炎症相关事件的微调因子。现有信息也支持miR-221沉默作为有前景的治疗干预手段的潜力。在本系统评价中，我们从2012年1月至2020年12月期间的主要数据库（PubMed、MedLine、Medscape、ASCO、ESMO）中选取论文，使用关键词“miR-221”以及与最重要的血液系统和实体恶性肿瘤以及一些非恶性疾病相关的特定关键词，以在现代分子医学视野中定义和表征失调的miR-221作为有价值的治疗靶点。从这一角度来看，我们发现miR-221发挥着重要作用。
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