癌症免疫治疗中金属配合物的发展日益受到关注。

Rising Interest in the Development of Metal Complexes in Cancer Immunotherapy.

机构信息

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, P. R. China.

出版信息

Chem Asian J. 2022 Jul 1;17(13):e202200270. doi: 10.1002/asia.202200270. Epub 2022 May 24.

DOI:10.1002/asia.202200270

PMID:35419865

Abstract

Metal complexes have shown great potential in cancer immunotherapy. This review briefly introduces the basic concepts and strategies of cancer immunotherapy and summarizes the recent discoveries on the immune effects of traditional platinum-based anticancer compounds. In addition, we also outline the latest research progresses on metal complexes for cancer immunotherapy focusing on platinum, ruthenium, iridium, rhenium and copper complexes. Finally, the research perspectives and unsolved problems on the applications of metallo-anticancer agents in cancer immunotherapy are purposed.

摘要

金属配合物在癌症免疫疗法中显示出巨大的潜力。本综述简要介绍了癌症免疫疗法的基本概念和策略，并总结了传统铂类抗癌化合物的免疫效应的最新发现。此外，我们还概述了目前针对铂、钌、铱、铼和铜配合物的癌症免疫疗法的金属配合物的最新研究进展。最后，提出了金属抗癌剂在癌症免疫疗法中的应用的研究展望和未解决的问题。