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抗菌药物耐药时代奶业中牛乳腺炎的防治:民族兽医药作为一种可行替代方法的选择

Combating Bovine Mastitis in the Dairy Sector in an Era of Antimicrobial Resistance: Ethno-veterinary Medicinal Option as a Viable Alternative Approach.

作者信息

Ajose Daniel Jesuwenu, Oluwarinde Bukola Opeyemi, Abolarinwa Tesleem Olatunde, Fri Justine, Montso Kotsoana Peter, Fayemi Omolola Esther, Aremu Adeyemi Oladapo, Ateba Collins Njie

机构信息

Food Security and Safety Niche Area, Faculty of Agriculture, Science and Technology, North-West University, Mmabatho, South Africa.

Department of Chemistry, Faculty of Natural and Agricultural Sciences, North-West University, Mmabatho, South Africa.

出版信息

Front Vet Sci. 2022 Apr 4;9:800322. doi: 10.3389/fvets.2022.800322. eCollection 2022.

Abstract

Bovine mastitis (BM) is the traditional infectious condition in reared cattle which may result in serious repercussions ranging from animal welfare to economic issues. Owing to the high costs associated with preventative practices and therapeutic measures, lower milk output, and early culling, bovine mastitis is accountable for most of the financial losses suffered in cattle farming. and coliform bacteria are the predominant pathogens for bovine mastitis. In addition, the occurrence of BM has been linked to lactation stage and poor management, in the latter case, the poor stabling conditions around udder hygiene. BM occurs throughout the world, with varying rates of infection in different regions. Despite the modern techniques, such as the appropriate milking practices that are applied, lower levels of pathogen vulnerability may help to prevent the development of the disease, BM treatment is primarily reliant on antibiotics for both prophylactic and therapeutic purposes. Nevertheless, as a result of the proliferation of bacterial agents to withstand the antibiotic effects, these therapies have frequently proven ineffectual, resulting in persistent BM. Consequently, alternative medicines for the management of udder inflammation have been researched, notably natural compounds derived from plants. This review focuses on BM in terms of its risk factors, pathogenesis, management, the molecular identification of causative agents, as well as the application of ethno-veterinary medicine as an alternative therapy.

摘要

牛乳腺炎(BM)是饲养牛群中的一种传统传染性疾病,可能会导致从动物福利到经济问题等一系列严重后果。由于预防措施和治疗手段成本高昂、产奶量降低以及过早淘汰,牛乳腺炎是养牛业遭受的大部分经济损失的原因。大肠杆菌是牛乳腺炎的主要病原体。此外,牛乳腺炎的发生与泌乳阶段和管理不善有关,在后一种情况下,乳房卫生周围的畜舍条件较差。牛乳腺炎在世界各地都有发生,不同地区的感染率各不相同。尽管采用了现代技术,如适当的挤奶方法,较低的病原体易感性可能有助于预防疾病的发展,但牛乳腺炎的治疗主要依赖抗生素进行预防和治疗。然而,由于细菌病原体对抗生素产生耐药性,这些疗法常常被证明无效,导致牛乳腺炎持续存在。因此,人们研究了用于治疗乳房炎症的替代药物,特别是从植物中提取的天然化合物。本综述重点关注牛乳腺炎的危险因素、发病机制、管理、病原体的分子鉴定,以及民族兽医学作为替代疗法的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b150/9014217/26484d63c3ba/fvets-09-800322-g0001.jpg

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