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一例自身免疫性神经胶质纤维酸性蛋白星形胶质细胞病,其磁共振成像表现类似于多发性硬化症。

A case of autoimmune glial fibrillary acidic protein astrocytopathy presenting with magnetic resonance imaging mimics of multiple sclerosis.

机构信息

Department of Neurology, Kanazawa University Graduate School of Medical Sciences, Ishikawa, Japan.

Department of Neurology, Gifu University Graduate School of Medicine, Gifu, Japan.

出版信息

Clin Neurol Neurosurg. 2022 Jul;218:107272. doi: 10.1016/j.clineuro.2022.107272. Epub 2022 Apr 29.

Abstract

Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is an inflammatory disorder of the central nervous system. On magnetic resonance imaging, the neuroradiological signature is a linear radial enhancement pattern of cerebral white matter (MRI). Dawson's fingers, on the other hand, and ovoid lesions with open-ring enhancement have long been recognized as distinct features of multiple sclerosis (MS). We herein report a case of autoimmune GFAP astrocytopathy presenting with these MRI findings specific to MS. Autoimmune GFAP astrocytopathy could mimic the MRI features of MS and should be included in the differential diagnosis of MS.

摘要

自身免疫性神经胶质纤维酸性蛋白 (GFAP) 星形胶质细胞病是一种中枢神经系统的炎症性疾病。在磁共振成像 (MRI) 上,神经放射学特征是脑白质的线性放射状增强模式 (MRI)。另一方面,道森氏指和具有开环增强的椭圆形病变一直被认为是多发性硬化症 (MS) 的独特特征。我们在此报告一例自身免疫性 GFAP 星形胶质细胞病,其 MRI 表现具有这些特定于 MS 的特征。自身免疫性 GFAP 星形胶质细胞病可能模仿 MS 的 MRI 特征,应纳入 MS 的鉴别诊断。

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