辽宁省沈阳市学龄儿童和青少年非酒精性脂肪性肝病的流行病学和生活方式调查。
Epidemiology and lifestyle survey of non-alcoholic fatty liver disease in school-age children and adolescents in Shenyang, Liaoning.
机构信息
Gastroenterology Department, The First Affiliated Hospital of China Medical University, No.155 North Nanjing Street, Heping District, Shenyang, 110001, Liaoning, China.
3Rd Clinical Department, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China.
出版信息
BMC Pediatr. 2022 May 17;22(1):286. doi: 10.1186/s12887-022-03351-w.
BACKGROUND
Non-alcoholic fatty liver disease (NAFLD) is diagnosed increasingly in children and adolescents. We aimed to investigate the prevalence and related influencing factors of NAFLD in school-aged children and adolescents in Shenyang, Liaoning Province. Furthermore, we analyzed the relationship between lifestyle and fatty liver.
METHODS
We conducted aprospective cohort study of 1309 school-aged children and adolescents between the ages of 7 and 18 years who underwent physical examination from November to December 2019. In addition, they were collected age, gender, learning stage, height, weight, BMI, waist circumference, hip circumference, and waist-hip ratio. Finally, a portion of the population was selected to complete a questionnaire survey to explore the impact of lifestyle habits on fatty liver disease.
RESULTS
NAFLD was present in 23.83% of subjects. The prevalence of children and adolescents was 22.73% and 24.43%, respectively. Fatty liver prevalence differs significantly by gender and learning stages. The highest rate of fatty liver was seen in obese children (71.68%). Moreover, exercise, diet, and parental factors can affect children with fatty liver.
CONCLUSIONS
NAFLD is very prevalent in children and adolescents in Shenyang city. Due to the close relationship between NAFLD and obesity, lifestyle plays a major role in the occurrence of NAFLD.
TRIAL REGISTRATION
The First Affiliated Hospital of China Medical University, [2020] 2020-258-2. Registered 6 June 2020-Retrospectively registered.
背景
非酒精性脂肪性肝病（NAFLD）在儿童和青少年中的诊断率日益增高。本研究旨在调查辽宁省沈阳市学龄儿童和青少年 NAFLD 的患病率及其相关影响因素，并分析生活方式与脂肪肝之间的关系。
方法
我们对 2019 年 11 月至 12 月期间进行体检的 1309 名 7 至 18 岁的学龄儿童和青少年进行了前瞻性队列研究。收集了他们的年龄、性别、学习阶段、身高、体重、BMI、腰围、臀围和腰臀比。最后，选择一部分人群完成问卷调查，以探讨生活习惯对脂肪肝的影响。
结果
23.83%的受试者患有 NAFLD。儿童和青少年的患病率分别为 22.73%和 24.43%。脂肪肝的患病率在性别和学习阶段上存在显著差异。肥胖儿童的脂肪肝发生率最高（71.68%）。此外，运动、饮食和父母因素都会影响儿童脂肪肝的发生。
结论
沈阳市儿童和青少年的 NAFLD 患病率很高。由于 NAFLD 与肥胖密切相关，生活方式在 NAFLD 的发生中起着重要作用。
试验注册
中国医科大学附属第一医院，[2020]2020-258-2。于 2020 年 6 月 6 日注册-回顾性注册。
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