克罗恩病的常规治疗方法。
Conventional Therapies for Crohn's Disease.
机构信息
Department of Internal Medicine, Mayo Clinic College of Medicine and Science, 200 First Street, Southwest, Rochester, MN 55905, USA.
Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, 200 First Street, Southwest, Rochester, MN 55905, USA.
出版信息
Gastroenterol Clin North Am. 2022 Jun;51(2):271-282. doi: 10.1016/j.gtc.2021.12.004. Epub 2022 Apr 22.
Crohn's disease is a chronic and progressive immune-mediated disease with increasing incidence worldwide. There are no curative therapies. The primary agents used in the treatment of Crohn's disease are aminosalicylates, corticosteroids, immunomodulators, and biologics. Each agent has different roles in the induction and maintenance of remission of disease. The biologics available include anti-TNF agents, anti-integrins, and anti-interleukins. The choice of initial biologic therapy should be determined through shared decision-making between the patient and provider.
克罗恩病是一种慢性、进行性的免疫介导性疾病，全球发病率呈上升趋势。目前尚无根治方法。治疗克罗恩病的主要药物包括氨基水杨酸类、皮质类固醇、免疫调节剂和生物制剂。每种药物在诱导和维持疾病缓解方面发挥不同作用。可用的生物制剂包括抗 TNF 制剂、抗整合素和抗白细胞介素。初始生物治疗的选择应通过患者和提供者之间的共同决策来确定。
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