[靶向巨噬细胞表面受体治疗炎症性肠病的研究进展]

[Research progress of targeting macrophage surface receptors in the treatment of inflammatory bowel disease].

作者信息

Zhang Ludan, Xu Huimei, Wang Tianyi, Wang Bianli, Zhang Shangdi, Zhang Dekui

机构信息

Department of Gastroenterology, the Second Hospital of Lanzhou University, Lanzhou 730000, China.

Laboratory Medicine Center, the Second Hospital of Lanzhou University, Lanzhou 730000, China.

出版信息

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2022 May;38(5):460-465.

PMID:35603655

Abstract

Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a chronic inflammatory disorder of the gastrointestinal tract with unknown etiology and pathogenesis. In the intestinal tissues of IBD patients, dysregulation of macrophages results in persistent intestinal inflammation. Macrophages are highly adaptable and their phenotypes and functions could be regulated by various factors in the microenvironment via ligand-receptor binding, thus affecting the progression of the disease.

摘要

炎症性肠病（IBD），包括溃疡性结肠炎（UC）和克罗恩病（CD），是一种病因和发病机制不明的胃肠道慢性炎症性疾病。在IBD患者的肠道组织中，巨噬细胞失调导致持续性肠道炎症。巨噬细胞具有高度适应性，其表型和功能可通过配体-受体结合受微环境中各种因素的调节，从而影响疾病的进展。